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April 2018: Changes to Chemistry Tests
Special Communication:
Upcoming Changes to Chemistry Tests
Effective April 17, 2018, there will be changes to the build, reference ranges, and special/clinical information for the following chemistry tests:
Build / Reference Range:
Specimen Validity pH, Urine: 4.5 – 8.0
Specimen Validity Specific Gravity, Urine: 1.002 – 1.030
Specimen Validity Creatinine, Urine
18 – 99 Years (Male): 46.8 – 314.5 mg/dL
18 – 99 Years (Female): 42.2 – 237.9 mg/dL
Specimen Validity Nitrites, Urine: > 50 mg/L
Specimen Validity Oxidants, Urine: < 200 mg/L
Specimen Validity Chromate, Urine: < 50 mg/L
Tests:
6-Monoacetylmorphine (6-MAM) Confirmation, Urine (U6AMCO)
Amphetamine Confirmation, Urine (UAMPC)
Benzodiazepines Conf, Ur (UBENZC)
Benzoylecgonine Confirmation/Quantitation (BECGO)
Buprenorphine Quant, Urine (UQNTBU)
Cannabinoid Confirmation, Ur (UTHCC)
Cocaine Confirmation, Urine (UCOCC)
Fentanyl and Metabolite, Urine (UFENT)
Methadone Quantitation, Urine (UQMET)
Opiate Confirmation, Urine (OPICON)
Oxycodone Confirmation, Urine (UOXYCC)
Quantitative Pain Panel, Urine (UQNTPP)
Tramadol and Metabolite, Quantitation (TRAQNT)
In addition to build and special/clinical information changes, the following tests will also have an adjustment to the reference range for Oxycodone:
Oxycodone:
Reference Range – Oxycodone, Urine: < 10 ng/mL
Special Information:
Specimen Validity Testing (SVT) analytes have the stability of up to 5 days at 2 – 8°C, as stated in the Instructions for Use (IFU). Based on the laboratory’s studies, this stability is based on samples that have reached an equilibrium.
- The introduction of oxidants to a urine sample will not be stable until an equilibrium is achieved.
- The time to reach equilibrium will vary dependent on the type and amount of oxidant used as an adulterant.
Clinical Information:
For Specimen Validity Interpretations, the following rules are applied:
Diluted
Creatinine: > or = 2 mg/dL, but < 20 mg/dL
Specific Gravity: > 1.0010 but < 1.0030
Substituted
Creatinine: < 2 mg/dL
Specific Gravity: < 1.0010 or > or = 1.0200
Adulterated
pH: < 3.0 or > or = 11.0
or Nitrites: > or = 500 mg/L
or Oxidants: > or = 200 mg/L
or Chromate: > or = 50 mg/L
Any additional information regarding this testing will be included in a future Technical Update. Please contact Client Services for further assistance.
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