Changes to Cyanide, Blood (CYANID) Testing
Cyanide, Blood (CYANID)
Effective August 15, 2018, Cyanide, Blood (CYANID) will have the following changes:
4 mL, whole blood
3 mL, whole blood
Lavender K2EDTA Tube
Ambient (room) temperature
Timing of specimen collection is dependent on time of exposure; test upon presentation to hospital.
72 hours, if tightly-capped
Non-smoker: < 20 μg/dL
Smoker: < 40 μg/dL
Sunday, Wednesday, and Friday
Frozen or refrigerated specimens will be rejected.
Clotted or hemolyzed specimens will be rejected.
Serum or plasma specimens are unacceptable.
Timing of specimen collection: dependent on time of exposure; test upon presentation to hospital.
This test is New York DOH approved.
This test is used to monitor cyanide exposure. Cyanide poisoning can cause hypoxia, dizziness, weakness and mental and motor impairment.
Elevated cyanide concentrations rarely indicate toxicity for patients on nitroprusside therapy. Thiocyanate should be monitored in patients on nitroprusside therapy for potential toxicity. Toxicity may occur with long-term nitroprusside use (longer than 7–14 days with normal renal function, and 3-6 days with renal impairment at greater than 2 μg/kg/min infusion rates).
Thiocyanate levels may be monitored on an every other day basis to assess potential thiocyanate toxicity and to indicate possible adjustments in dosage.
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