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CC-SIGN® Hematologic Neoplasm Next-Generation Sequencing Panel
Physicians and pathologists can use this customizable panel to assist in determining diagnostic, prognostic, and predictive markers, and the selection of the most appropriate therapies for their patients.
Performed on blood or bone marrow, this laboratory developed test is intended to detect variants associated with hematologic neoplasms, including:
– Acute myeloid leukemia (AML)
– Acute lymphoblastic leukemia (ALL)
– Chronic lymphocytic leukemia (CLL)
– Myeloproliferative neoplasms (MPN)
– Myelodysplastic syndrome (MDS)
Available Subpanels
Myeloid – 50 genes
Acute Lymphoblastic Leukemia – 26 genes
Chronic Lymphoproliferative Disorders – 7 genes
Myeloproliferative Neoplasms – 3 genes
Test Overview
Test Name
Available Subpanels
CPT Code
81455
Turnaround Time
10 days (upon specimen receipt)
Specimen Requirements
Bone Marrow Aspirate: 2 mL
Peripheral Blood: 4 mL
Do not freeze specimens.
Specimen Shipping Address
Cleveland Clinic Laboratories
2119 E. 93rd Street, L15
Cleveland, OH 44106
Specimens must be sent via UPS, FedEx, or DHL – review our Shipping Information for more details.
Targeted Gene Regions
Genes interrogated, including relevant transcripts and exons, are listed in alphabetical order.
A
Gene, Transcript, Exons
ABL1
NM_005157.5
4-6
ASXL1
NM_15338.5
10-13
B
Gene, Transcript, Exons
BCOR
NM_17745.5
2-15
BCORL1
NM_021946.4
1-12
BRAF
NM_004333.4
15
C
Gene, Transcript, Exons
CALR
NM_004343.3
9
CBL
NM_005188.3
8-9
CDKN2A
NM_000077.4
1-2
CDKN2A
NM_058195.3
1
CEBPA
NM_004364.4
1
CSF3R
NM_000760.3
14-17
CUX1
NM_001202543.1
15-24
CUX1
NM_001913.4
1-23
D
Gene, Transcript, Exons
DDX41
NM_016222.3
1-17
DNMT3A
NM_022552.4
2-23
E
Gene, Transcript, Exons
EED
NM_003797.4
1-12
ETNK1
NM_018638.4
3
ETV6
NM_001987.4
1-8
EZH2
NM_004456.4
2-20
F
Gene, Transcript, Exons
FBXW7
NM_018315.4
7-11
FLT3
NM_004119.2
14-17, 19-20
G
Gene, Transcript, Exons
GATA1
NM_002049.3
2,4
GATA2
NM_032638.4
2-6
GNAS
NM_000516.5
8-11
I
Gene, Transcript, Exons
IDH1
NM_005896.3
4
IDH2
NM_002168.3
4
IKZF1
NM_006060.5
2-3, 5-7
J
Gene, Transcript, Exons
JAK2
NM_004972.3
12-16
JAK3
NM_000215.3
11-18
K
Gene, Transcript, Exons
KDM6A
NM_021140.3
1-29
KIT
NM_000222.2
2, 8-11, 13, 17
KMT2A
NM_005933.3
1-36
KRAS
NM_004985.4
2-4
L
Gene, Transcript, Exons
LUC7L2 (C7orf55)
NM_001244585.1
2-11
M
Gene, Transcript, Exons
MPL
NM_005373.2
10-11
MYD88
NM_002468.4
5
N
Gene, Transcript, Exons
NF1
NM_000267.3
1-57
NF1
NM_001042492.2
31
NOTCH1
NM_17617.4
26, 27, 34
NPM1
NM_002520.6
8-11
NRAS
NM_002524.4
2-4
P
Gene, Transcript, Exons
PAX5
NM_016734.2
Exons 1-10
PHF6
NM_001015877.1
2-10
PIGA
NM_002641.3
2-6
PPM1D
NM_003620.3
1-6
PRPF8
NM_006445.3
2-43
PTEN
NM_000314.6
1-9
PTPN11
NM_002834.3
3-4, 12-13
R
Gene, Transcript, Exons
RAD21
NM_006265.2
2-14
RIT1
NM_006912.5
5
RUNX1
NM_001754.4
2-9
RUNX1
NM_001122607.1
5
S
Gene, Transcript, Exons
SETBP1
NM_015559.2
4*
SF3B1
NM_012433.3
13-16
SH2B3
NM_005475.2
2
SMC1A
NM_006306.3
1-25
SMC3
NM_005445.3
1-29
SRSF2
NM_003016.4
1-2
STAG2
NM_00104279.2
3-35
STAT3
NM_003150.3
20-21
STAT5B
NM_012448.3
16-18
SUZ12
NM_015355.3
1-16
* Exon is only partially analyzed from genomic coordinates chr18:42531679-42532175.
T
Gene, Transcript, Exons
TET2
NM_001127208.2
3-11
TP53
NM_000546.5
2-11
U
Gene, Transcript, Exons
U2AF1
NM_006758.2
2, 6
W
Gene, Transcript, Exons
WT1
NM_000378.4
1-9
Z
Gene, Transcript, Exons
ZRSR2
NM_005089.3
1-11
