Hematopathology Consultative Services
Our test menu combines the state-of-the-art laboratory diagnostics required in modern hematology practice with a foundation of expert consultation for bone marrow biopsies and lymphoid tissues.
A wide range of offerings in flow cytometry, molecular hematology, immunohistochemistry, and cytogenetic karyotyping help answer today’s complex hematology questions.
The added support of our subspecialty-trained hematopathologists provides interpretations to our clients with meaningful clinical context. Our services are designed to be flexible based on the needs of each client and each case, from performing a single test to providing full-service consultation.
Bone Marrow Consultation
Bone marrow aspirates and biopsies are performed in the evaluation of patients with suspected hematologic disease or hematolymphoid disorders. The best value for the patient is achieved when the treating physician provides pertinent clinical information, an adequate specimen is obtained, and samples are packed and shipped properly. Our Bone Marrow Biopsy Consultation Kit provides the necessary materials to ensure specimen integrity during shipment to our laboratories.
In some cases, additional studies may be performed on this material, such as cytochemistry, immunohistochemistry, or molecular, at the discretion of the pathologist.
Flow cytometric immunophenotyping services are available on bone marrow samples for the evaluation of suspected hematologic malignancy. This includes a morphologic review of submitted stained or unstained aspirate smears, along with four-color flow cytometric analysis, and interpretation by a staff hematopathologist. This review includes an initial morphologic evaluation to determine the appropriateness of the panel requested.
Cleveland Clinic Laboratories offers a full range of expert consultative services for bone marrow evaluation and interpretation.
- Evaluation of Prepared Peripheral Blood Smears
- Bone Marrow Aspirate Smears
- Touch Imprints
- Core Biopsies
- Clot Sections (if available)
- Full Morphologic Interpretation of Bone Marrow Specimens
Cleveland Clinic Laboratories offers comprehensive, expert consultative services for the evaluation of lymphoproliferative disorders.
Flow Cytometric Immunophenotyping with Histopathologic Evaluation
Clients may send fresh tissue in tissue culture medium for flow cytometric immunophenotyping. When routinely processed tissue is available, histologic slides and paraffin blocks are forwarded for evaluation and diagnosis.
Refer to flow cytometry and surgical pathology in the Test Directory for more information.
Histopathologic Evaluation, Paraffin-Embedded Tissues
Specimens (slides and tissue blocks) may be sent for diagnostic consultation. Ancillary studies, such as immunohistochemistry and molecular diagnostics, will be performed if required.
Refer to surgical pathology in the Test Directory for more information.
Flow Cytometry Only
Specimens may be sent fresh in tissue culture medium for flow cytometric immunophenotyping with interpretation by a staff hematopathologist.
A full range of ancillary techniques—including flow cytometric immunophenotyping, immunohistochemistry, and molecular diagnostics—is available to interested healthcare providers.
The Flow Cytometry Laboratory provides a wide range of immunophenotyping services supported by expert hematopathology staff and personnel.
Services include the assessment of leukemias and lymphomas, lymphocyte subsetting for immunodeficiency states and transplantation immunosuppression status, hematopoietic stem cell enumeration, screening for paroxysmal nocturnal hemoglobinuria, and human leukocyte antigen (HLA) B27 testing.
Flow Cytometry Services
Blood samples are assessed for lymphocyte subsetting in whole blood, which may be performed as part of the initial diagnosis or in the setting of therapeutic monitoring.
HLA-B27 testing is used to identify the B27 protein on the surface of white cells in whole blood. The presence of this protein is strongly associated with several rheumatic disorders and ankylosing spondylitis (AS), a chronic inflammatory disease of the musculoskeletal system.
Blood, bone marrow, body fluid, and tissue samples suspected of being involved by leukemia or lymphoma undergo morphologic review and multiparameter flow cytometric immunopheno-typing using antibody panels specifically designed to detect and characterize hematologic malignancies. Hematopathologists interpret the results in the context of morphologic findings, and provide information on clinical-pathologic correlations to assist clients in accurate and timely diagnosis.
Turnaround for most pathology cases is within 48 hours.
Our staff is available for consultation during any stage of diagnosis or treatment.
Flexible Billing Options
Options include third-party and client billing that can be customized to your needs.
Concise, in-depth reports are available for each consultation.