Precision Medicine – Challenges Associated with Annotation and Interpretation of Somatic Mutation Data – Presented by: Roger Klein, MD, JD

The past several years have seen a significant increase in the demand for somatic mutation testing in human cancers in order to specifically tailor therapeutic management strategies to specific patients. Many laboratories have begun testing for various numbers of mutations in large numbers of genes using massively parallel sequencing to provide genomic profiles that would direct therapeutic selection. This lecture will discuss the challenges associated with data analysis from the perspective of annotation, and interpretation for routine clinical practice.