There are several hematolymphoid lesions which are at the interface between processes which are clearly malignant and others which are clinically benign, including in situ lymphomas, EBV-associated lymphoproliferative disorders, and idiopathic cytopenias of undetermined significance. As more data is accumulated our understanding of these entities is constantly evolving. Despite increases in knowledge, these borderline lesions remain difficult to diagnose.
This course will be based on case examples which will be available for review as digital slides and static images prior to the meeting. It is designed for pathologists in training, and practicing hematopathologists and surgical pathologists. After the course, registrants will be given access to PowerPoint slides used during the presentation.
Topics to be discussed include in situ lymphomas, cutaneous pseudolymphomas, clonal T-cell populations detected during immune-altered states, monoclonal gammopathy of undetermined significance, non-post-transplant EBV-associated lymphoproliferative disorders, chronic eosinophilia, and idiopathic cytopenia of undermined significance, as well as other related lesions. Emphasis will be placed on morphologic features and differential diagnosis of these entities, as well as guidance regarding appropriate ancillary testing. A brief review of current understanding of pathogenesis and prognosis will also be discussed for each lesion.