Coccidioides Ab, CF




Test Mnemonic

COCICF

CPT Codes

  • 86635 - QTY (1)

LOINC ®

33380-7

Includes

  • Coccidioides Antibody by CF

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumSST (Gold) RefrigeratedSeparate serum from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube. Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Label specimens plainly as 'acute' and 'convalescent.'

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.6 mL     

Stability

Environmental Condition Description
AmbientAfter separation from cells: 48 hours
RefrigeratedAfter separation from cells: 2 weeks
FrozenAfter separation from cells: 1 year (Avoid repeated freeze/thaw cycles)

Days Performed

Sun - Sat

Turnaround Time

3 - 6 days

Methodology

Name Description
Semi-Quantitative Complement Fixation 

Special Info

Non-serum specimens and serum that is contaminated, hemolyzed, icteric or lipemic will be rejected. This test is New York DOH approved.

Clinical Info

CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired specimens are preferred. Acute and convalescent specimens (drawn at least 21 days apart), showing at least a fourfold rise in titer, are diagnostic. Negative fungal serology does not rule out the possibility of current infection. Any titer suggests past or current infection and may aid in monitoring coccidioidomycosis (Valley fever) and treatment response. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative Complement Fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; anticoccidioidal CF antibody titers in excess if 1:16 may indicate disseminated infection. CF serology may be used to follow therapy.