IDH1/IDH2 Mutation, Blood/Bone marrow
Test Mnemonic
IDH12
CPT Codes
- 81120 - QTY (1)
- 81121 - QTY (1)
Aliases
- 15q21-qter
- IDH1 and IDH2 Mutation Analysis, exon 4
- IDH1/IDH2 Mutation Analysis, exon 4 for blood, bone marrow
- Isocitrate dehydrogenase 1 (NADP+) soluble,
- Isocitrate dehydrogenase 2 (NADP+) Mitochondrial,
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Whole blood | EDTA (Lavender) | Refrigerated | Do not freeze. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Bone marrow | EDTA (Lavender) | Refrigerated | Do not freeze. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Whole blood and Bone marrow |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | Blood, bone marrow: 5 days |
| Ambient | Blood, bone marrow: 24 hours |
| Frozen | Blood, bone marrow: Unacceptable |
Days Performed
Sun, Tue, Thu
Turnaround Time
8 - 15 days
Methodology
| Name | Description |
|---|---|
| Polymerase Chain Reaction/Sequencing |
Reference Range
Special Info
Plasma, serum, FFPE tissue blocks/slides, or frozen tissue, or extracted DNA will be rejected. Specimens collected in anticoagulants other than EDTA or sodium heparin are unacceptable. Clotted or grossly hemolyzed specimens will be rejected. This test is New York DOH approved.
Clinical Info
Detect IDH1 and IDH2 mutations in whole blood or bone marrow. May have prognostic significance in patients with hematologic malignancies, depending on the clinical and genetic context.