LC-MS/MS Thyroglobulin measurement for Thyroglobulin Antibody Interference
Test Mnemonic
TGMSMS
CPT Codes
- 84432 - QTY (1)
Aliases
- Thyroglobulin Interference
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1.5 mL | Serum | SST (Gold) | Refrigerated | Separate from cells and transfer into standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1.5 mL | Serum | No additive (Red) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube. | |
| 1.5 mL | Plasma | Sodium or Lithium heparin (Green) | Refrigerated | Separate from cells and transfer into standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.7 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 1 day |
| Refrigerated | After separation from cells: 1 week |
| Frozen | After separation from cells: 1 year |
Days Performed
Mon, Wed, Thu, Sat
Turnaround Time
2 - 7 days
Methodology
| Name | Description |
|---|---|
| High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) |
Reference Range
| Thyroglobulin, LC-MS/MS | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| 4 Years | 7 Years | Normal | 4.1 - 40.5 | ng/mL | 8 Years | 17 Years | Normal | 0.8 - 29.4 | ng/mL | Freetext | 6 months - 3 years: 7.4 - 48.7 ng/mL | Freetext | 18 Years and older: 1.3 - 31.8 ng/mL |
Special Info
Samples left ambient for greater than 1 day or specimens that are grossly lipemic will be rejected. This test is New York DOH approved.
Clinical Info
Recommended test for quantifying thyroglobulin in individuals with antithyroglobulin antibodies. Aids in surveillance of residual/recurrent thyroid cancer in individuals who have developed antibodies to thyroglobulin. The lower limit of detection is 0.5 ng/mL.