Porphyrins, Urine Fractionated




Test Mnemonic

UPORFR

CPT Codes

  • 84120 - QTY (1)

Includes

  • Creatinine, Ur mg/dL
  • Creatinine mg/day
  • Uroporphyrin-ratio to CRT
  • Heptacarboxylate-ratio to CRT
  • Coproporphyrin I-ratio to CRT
  • Coproporphyrin III-ratio to CRT

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4 mLUrine, 24-hour (well-mixed)Clean containerRefrigerate during collection.FrozenProtect specimen from light.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4 mLUrine, randomClean container FrozenProtect specimen from light.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mL     

Stability

Environmental Condition Description
AmbientUnacceptable
Refrigerated4 Days
Frozen1 month

Days Performed

Mon - Fri

Turnaround Time

2 - 6 days

Methodology

Name Description
High Performance Liquid Chromatography (HPLC) 

Reference Range

Coproporphyrin III-ratio to CRT
Sex Age From Age To Type Range Range Unit
       Normal0 - 14umol/mol crt
Coproporphyrin I-ratio to CRT
Sex Age From Age To Type Range Range Unit
       Normal0 - 6umol/mol crt
Heptacarboxylate-ratio to CRT
Sex Age From Age To Type Range Range Unit
       Normal0 - 2umol/mol crt
Uroporphyrin
Sex Age From Age To Type Range Range Unit
       Normal0 - 10%
       Normal0 - 30%
Uroporphyrin-ratio to CRT
Sex Age From Age To Type Range Range Unit
       Normal0 - 4umol/mol crt

Special Info

Indicate total volume and collection time with specimen. Protect specimen from light. Body fluids other than urine will be rejected. This test is New York DOH approved.

Clinical Info

Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine). Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute attack forms of porphyrias such as acute intermittent porphyria (AIP) require urine porphobilinogen (PBG) testing.