Porphyrins, Urine Fractionated
Test Mnemonic
UPORFR
CPT Codes
- 84120 - QTY (1)
Includes
- Creatinine, Ur mg/dL
- Creatinine mg/day
- Uroporphyrin-ratio to CRT
- Heptacarboxylate-ratio to CRT
- Coproporphyrin I-ratio to CRT
- Coproporphyrin III-ratio to CRT
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, 24-hour (well-mixed) | Clean container | Refrigerate during collection. | Frozen | Protect specimen from light. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, random | Clean container | Frozen | Protect specimen from light. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 4 Days |
| Frozen | 1 month |
Days Performed
Mon - Fri
Turnaround Time
2 - 6 days
Methodology
| Name | Description |
|---|---|
| High Performance Liquid Chromatography (HPLC) |
Reference Range
| Coproporphyrin III-ratio to CRT | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 14 | umol/mol crt | |||
| Coproporphyrin I-ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 6 | umol/mol crt | |||
| Heptacarboxylate-ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 2 | umol/mol crt | |||
| Uroporphyrin | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 10 | % | Normal | 0 - 30 | % |
| Uroporphyrin-ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 4 | umol/mol crt |
Special Info
Indicate total volume and collection time with specimen. Protect specimen from light. Body fluids other than urine will be rejected. This test is New York DOH approved.
Clinical Info
Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine). Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute attack forms of porphyrias such as acute intermittent porphyria (AIP) require urine porphobilinogen (PBG) testing.