SF3B1 Mutation Analysis Blood

Test Mnemonic


CPT Codes

  • 81347 - QTY (1)

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4 mLBloodEDTA (Lavender)AmbientAmbient 


Environmental Condition Description
Ambient48 Hours
Refrigerated7 Days

Days Performed

2 days per week

Turnaround Time

10 days


Name Description
Next Generation DNA Sequencing 

Special Info

The following genes are interrogated: SF3B1.

Clinical Info

Somatic mutations in SF3B1 have been reported in 15%-30% of myelodysplastic syndrome (MDS) cases, including the vast majority of MDS cases with ring sideroblasts phenotype (70-80%), in chronic lymphocytic leukemia (CLL, 15%), and, at a lower rate, in other myeloid neoplasms and some solid tumors (PMID: 21909114, PMID: 24523246).