SF3B1 Mutation Analysis Bone Marrow
Test Mnemonic
SF3B1M
CPT Codes
- 81347 - QTY (1)
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Aspirate, bone marrow | EDTA (Lavender) | Ambient | Ambient |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 48 Hours |
| Frozen | Unacceptable |
| Refrigerated | 7 Days |
Days Performed
2 days per week
Turnaround Time
10 days
Methodology
| Name | Description |
|---|---|
| Next Generation DNA Sequencing |
Special Info
The following genes are interrogated: SF3B1.
Clinical Info
Somatic mutations in SF3B1 have been reported in 15%-30% of myelodysplastic syndrome (MDS) cases, including the vast majority of MDS cases with ring sideroblasts phenotype (70-80%), in chronic lymphocytic leukemia (CLL, 15%), and, at a lower rate, in other myeloid neoplasms and some solid tumors (PMID: 21909114, PMID: 24523246).