Bethesda Inhibitor




Test Mnemonic

BETHDA

CPT Codes

  • 85335 - QTY (1)
  • 85240 - QTY (1)
  • 85210 - QTY (1)
  • 85220 - QTY (1)
  • 85230 - QTY (1)
  • 85250 - QTY (1)
  • 85260 - QTY (1)
  • 85270 - QTY (1)

Aliases

  • Factor IX Inhibitor
  • Factor VIII Inhibitor
  • Inhibitor Assay

Includes

  • Bethesda Units

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
Volume1 mLTypePlasmaContainerSodium citrate (Lt. Blue)Collect Temperature Transport TemperatureFrozenSpecial InstructionsSend two 1 mL aliquots

Stability

Environmental Condition Description
Environmental ConditionAmbientDescription4 hours
Environmental ConditionRefrigeratedDescriptionUnacceptable
Environmental ConditionFrozenDescription14 days at -20 C; 6 months at -70 C

Days Performed

Mon - Fri

Turnaround Time

1 - 3 days

Methodology

Name Description
NameClotting AssayDescription 

Reference Range

Bethesda Inhibitor
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToNormalType< or = 0.4RangeInhib Unit
Factor II Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType29 - 72Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType36 - 96Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType37 - 106Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType50 - 109Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType66 - 120Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType78 - 120Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType74-111Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType67-108Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType77-151Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%
Factor IX Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType21 - 97Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType21 - 97Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType29 - 86Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType29 - 120Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType50 - 144Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType66 - 110Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType88 - 95Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType83 - 130Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType77 - 173Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%
Factor V Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType42 - 100Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType53 - 134Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType73 - 124Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType57 - 122Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType65 - 118Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType93 - 118Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType74 - 108Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType65 - 92Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType73 - 139Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%
Factor VII Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType23 - 116Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType29 - 160Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType35 - 154Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType32 - 160Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType39 - 142Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType45 - 130Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType43 - 134Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType48 - 129Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType55 - 160Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%
Factor VIII Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType22 - 207Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType22 - 179Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType26 - 182Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType34 - 145Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType38 - 127Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType59 - 165Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType58 - 153Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType53 - 152Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType50 - 173Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%
Factor VIII Chromogenic
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType22-179Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType22-155Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType26-158Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType34-126Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType38-110Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType59-143Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType58-133Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType53-132Range%
Bethesda Inhibitor Sex17 YearsAge From999 YearsAge ToNormalType50-150Range%
Factor X Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType15 - 73Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType23 - 85Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType38 - 93Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType43 - 115Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType46 - 127Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType61 - 124Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType57 - 108Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType52 - 126Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType73 - 163Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%
Factor XI Assay
Sex Age From Age To Type Range Range Unit
Bethesda Inhibitor Sex  DaysAge From1 DaysAge ToNormalType10 - 91Range%
Bethesda Inhibitor Sex2 DaysAge From5 DaysAge ToNormalType23 - 120Range%
Bethesda Inhibitor Sex6 DaysAge From30 DaysAge ToNormalType27 - 109Range%
Bethesda Inhibitor Sex1 MonthsAge From3 MonthsAge ToNormalType42 - 134Range%
Bethesda Inhibitor Sex4 MonthsAge From11 MonthsAge ToNormalType39 - 185Range%
Bethesda Inhibitor Sex1 YearsAge From5 YearsAge ToNormalType57 - 207Range%
Bethesda Inhibitor Sex6 YearsAge From10 YearsAge ToNormalType53 - 165Range%
Bethesda Inhibitor Sex11 YearsAge From16 YearsAge ToNormalType51 - 134Range%
Bethesda Inhibitor Sex17 YearsAge From99 YearsAge ToNormalType68 - 175Range%
Bethesda Inhibitor Sex  YearsAge From99 YearsAge ToUrgentTypeAfter Pathologist Review: < 5Range%

Special Info

Indicate coagulation factor to be tested. 3.2% sodium citrate is the preferred anticoagulant recommended by NCCLS. If inhibitor to porcine Factor VIII is needed, please supply porcine Factor VIII with patient sample. Appropriate factor assay requested will be performed and billed when requesting a Bethesda inhibitor.

Clinical Info

Factor VIII inhibitor: Factor VIII inhibitors most commonly occur in patients with Factor VIII deficiency (Hemophilia A) after treatment with factor replacement. Factor VIII inhibitors can also arise de novo in the elderly in a patient with lymphoproliferative disorders, post-partum and a patient with automimmune disorders.Factor IX inhibitor: Most commonly occurs in a patient with Factor IX deficiency (Hemophilia B) after treatment with factor IX replacement. De novo Factor IX inhibitors can occur but are rare. Porcine Factor VIII Inhibitor: Useful to determine the cross reactivity of factor VIII inhibitor against porcine factor VIII. If a factor VIII inhibitor is suspected, this assay should be ordered in addition to Factor VIII inhibitor level if porcine factor VIII is a therapeutic option. Factor VIII inhibitor: Inhibitor titers < 5 Bethesda units are considered low titer inhibitors; those > or = 5 Bethesda units are considered high titer inhibitors. Porcine Factor VIII inhibitor: A high titer (> 5 Bethesda units) against Porcine Factor VIII may make Porcine Factor VIII ineffective as a potential therapy for a Factor VIII inhibitor.