Hypercoagulation Diagnostic Interpretive Panel




Test Mnemonic

HYPER

CPT Codes

  • 86147 - QTY (3)
  • 85610 - QTY (1)
  • 85730 - QTY (1)
  • 85384 - QTY (1)
  • 85303 - QTY (1)
  • 86140 - QTY (1)
  • 81240 - QTY (1)
  • 85390 - QTY (1)
  • 85670 - QTY (1)
  • 85520 - QTY (1)
  • 85240 - QTY (1)
  • 85307 - QTY (1)
  • 85300 - QTY (1)
  • 85306 - QTY (1)
  • 85730 - QTY (1)
  • 85598 - QTY (1)
  • 85732 - QTY (1)
  • 85730 - QTY (1)

Aliases

  • Hypercoagulation Panel
  • Hyper Panel

Includes

  • FVIIIC
  • Antithrombin Assay
  • PROT S Clot
  • STACLOT LA
  • APC
  • Prothrombin Time (PT)
  • APTT
  • Fibrinogen
  • Cardiolipin Antibodies
  • C-Reactive Protein
  • APTTSC
  • TT
  • ANTIXA
  • Protein C Functional
  • PTGEN

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
Volume2 mLTypeSerumContainerSST (Gold)Collect Temperature Transport TemperatureFrozenSpecial InstructionsIndicate clearly which tube is plasma and which tube is serum. Submit Coagulation Consultation Patient History Form.
Volume4 mLTypeWhole bloodContainerEDTA (Lavender)Collect Temperature Transport TemperatureRefrigeratedSpecial Instructions 
Volume6 mLTypePlasmaContainerSodium citrate (Lt. Blue)Collect TemperatureSee noteTransport TemperatureCentrifuge, aliquot and freeze ASAP.Special InstructionsCollection tubes must be filled to total fill volume. Inadequately filled and clotted tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into separate tubes and label with Epic Beaker labels, DO NOT POUR SPECIMENS TOGETHER. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
Volume2 mLType Container Collect Temperature Transport Temperature Special InstructionsWhole blood EDTA (Lavender)
Volume1 mLType Container Collect Temperature Transport Temperature Special InstructionsSerum
Volume3 mLType Container Collect Temperature Transport Temperature Special Instructions Citrated plasma. NOTE: If only the minimum volume is received, some reflex testing may not be able to be performed.

Stability

Environmental Condition Description
Environmental ConditionAmbientDescriptionMain campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE.
Environmental ConditionFrozenDescriptionFor Non-Testing sites, Frozen Plasma is ACCEPTABLE. Centrifuge samples, then aliquot plasma into separate tubes and label with Epic Beaker labels. DO NOT COMBINE TUBES. Specimens should be frozen (-20° C or colder) and they are stable for 2 weeks. (6 months at -70° C)
Environmental ConditionRefrigeratedDescriptionUnacceptable

Days Performed

Mon - Fri

Turnaround Time

3 - 5 days

Methodology

Name Description
NameRefer to individual componentsDescription 

Reference Range

APTT Screen
Sex Age From Age To Type Range Range Unit
APTT Screen Sex  DaysAge From1 DaysAge ToNormalType28.2-47.4Rangesec
APTT Screen Sex1 MonthsAge From3 MonthsAge ToNormalType21.7-43.5Rangesec
APTT Screen Sex2 DaysAge From5 DaysAge ToNormalType22.9-52.0Rangesec
APTT Screen Sex6 DaysAge From30 DaysAge ToNormalType23.1-48.0Rangesec
APTT Screen Sex4 MonthsAge From11 MonthsAge ToNormalType25.3-37.3Rangesec
APTT Screen Sex1 YearsAge From5 YearsAge ToNormalType21.3-31.6Rangesec
APTT Screen Sex6 YearsAge From10 YearsAge ToNormalType23.1-31.6Rangesec
APTT Screen Sex11 YearsAge From16 YearsAge ToNormalType23.1-32.5Rangesec
APTT Screen Sex17 YearsAge From99 YearsAge ToNormalType24.0-35.1Rangesec
Thrombin Time
Sex Age From Age To Type Range Range Unit
APTT Screen Sex  DaysAge From1 DaysAge ToNormalType< 17.3Rangesec
APTT Screen Sex2 DaysAge From5 DaysAge ToNormalType< 17.9Rangesec
APTT Screen Sex6 DaysAge From30 DaysAge ToNormalType< 17.9Rangesec
APTT Screen Sex1 MonthsAge From3 MonthsAge ToNormalType< 18.2Rangesec
APTT Screen Sex4 MonthsAge From11 MonthsAge ToNormalType< 19.1Rangesec
APTT Screen Sex1 YearsAge From999 YearsAge ToNormalType< 18.6Rangesec

Special Info

Patient Preparation: Discontinue coumadin therapy for 7 days, heparin therapy for 2 days and thrombolytic therapy for 7 days prior to test, if possible. 3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. Per Pathologist review, the following tests may be ordered and billed: ATIII Antigen (85301); PTT Incubated Mixing Add On (85730, 85732 x2); Dilute Russell Viper Venom (85613); Platelet Neutralization (85597); Factor V Leiden (81241); Reptilase (85635); Fibrinogen Antigen (85385); D-Dimer (85379); Prot C Immunologic (85302); Factor 8 chromogenic (85240); Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation and a medication list.

Clinical Info

Use in the evaluation of congenital or acquired disorders associated with a hypercoagulable state.