17-Hydroxyprogesterone, Urine
Test Mnemonic
U17OHP
CPT Codes
- 83498 - QTY (1)
Aliases
- 17-Hydroxy Progesterone
- 17-OH Progesterone
Includes
- Urine 17-Hydroxyprogesterone
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 10 mL | Urine, random | Clean container | Frozen | If possible, discontinue any corticosteroid, ACTH, estrogen, or gonadotropin medications for at least 48 hours prior to collection. Place specimen on ice. Separate specimens must be submitted when multiple tests are ordered. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Frozen | 6 months |
| Refrigerated | 4 days |
| Ambient | 1 hour |
Days Performed
Varies
Turnaround Time
8 - 14 days
Methodology
| Name | Description |
|---|---|
| Radioimmunoassay (RIA) |
Reference Range
Special Info
If possible, discontinue any corticosteroid, ACTH, estrogen, or gonadotropin medications for at least 48 hours prior to collection. Place specimen on ice. Separate specimens must be submitted when multiple tests are ordered.
Clinical Info
17-Hydroxy Progesterone is a steroid derived primarily from enzymatic metabolism of Progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to Androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as Pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by Dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with Polycystic Ovarian Disease and Congenital Adrenal Hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21a-Hydroxylase Deficient Congenital Adrenal Hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.