Clobazam and Metabolite, Quantitative, Serum or Plasma
Test Mnemonic
CLOBAZ
CPT Codes
- 80339/G0480 - QTY (1)
Aliases
- Onfi
- Sympazan
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Serum | No additive (Red) | Refrigerated | Draw specimen immediately before next scheduled dose; the therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. Centrifuge within 2 hours of collection and transfer serum into standard plastic aliquot tube. Serum gel tube is not acceptable. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | Lavender EDTA | Refrigerated | Draw specimen immediately before next scheduled dose; the therapeutic range is based on the predose (trough) draw collection at steady-state concentration. Centrifuge within 2 hours of collection and transfer plasma into standard plastic aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 72 hours |
| Refrigerated | 14 days |
| Frozen | 2 months; avoid repeated freeze thaw cycles |
Days Performed
Mon, Wed, Sat
Turnaround Time
2 - 7 days
Methodology
| Name | Description |
|---|---|
| Quantitative Liquid Chromatography - Tandem Mass Spectrometry |
Reference Range
| Clobazam | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 30 - 300 | ng/mL | |||
| N - desmethylclobazam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| 300 - 3000 | ng/mL |
Special Info
Do not draw serum separator tubes. Draw specimen immediately before next scheduled dose. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. This test is New York state approved.
Clinical Info
Useful for monitoring clobazam therapy. The results of this test should be interpreted in conjunction with the patient’s physical signs, symptoms, and other laboratory test results. Most individuals display optimal response to clobazam when serum levels of clobazam are between 30 - 300 ng/mL and n-desmethylclobazam are between 300 - 3000 ng/mL. When cloabzam levels are > 500 ng/mL or n-desmethylclobazam levels are > 5000 ng/mL, risk of toxicity is increased. Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range. Therefore, interpretation should include clinical evaluation.