Protein S Clottable
Test Mnemonic
PRSCLT
CPT Codes
- 85306 - QTY (1)
LOINC ®
27822-6
Aliases
- Pro S Functional
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | Sodium citrate (Lt. Blue) | Frozen |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Days Performed
Mon - Fri
Turnaround Time
1 - 3 days
Methodology
| Name | Description |
|---|---|
| Clotting Assay |
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. If protein S clottable is decreased, suggest ordering factor VIII, APC - R and protein S immunologic.
Clinical Info
For use in the evaluation of hypercoagulable state due to congenital or acquired protein S deficiency. This is a functional assay which detects the amount of Protein S in plasma. Coumadin will lower protein S levels. Elevated factor VIII levels (>250%) and APC resistance (factor V Leiden) can lower protein S clottable. High heparin concentration (> 1 unit/ mL) and lupus anticoagulant can falsely elevate protein S clottable.