Histone IgG Aby
Test Mnemonic
HISTN
CPT Codes
- 86235 - QTY (1)
LOINC ®
29996-6
Aliases
- H2A-H2B- DNA Auto Antibodies
- Histone DNA Complex IgG Auto Aby
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 24 hours |
| Refrigerated | 7 days |
| Frozen | 1 year; 2 freeze thaw cycles are acceptable |
Days Performed
Thu
Turnaround Time
1 - 8 days
Methodology
| Name | Description |
|---|---|
| Enzyme-Linked Immunosorbent Assay (ELISA) |
Special Info
Negative:<1.0 units, Weak positive: 1.0-1.5 units, Moderate positive: 1.6-2.5 units, Strong positive: >2.5 units Results are obtained with the Inova QUANTA Lite Histone ELISA kit. Histone values obtained with different manufacturers' assay methods may not be used interchangeably. The magnitude of the reported IgG levels cannot be correlated to an endpoint titer.
Clinical Info
Anti-histone IgG antibody test is used as an aid in the diagnosis of idiopathic and drug-induced systemic lupus erythematosus. It may be positive in other systemic autoimmune diseases. Clinical correlation is required.