N-methyl-D-Aspartate Receptor (NMDAR) Antibody, IgG, CSF, Reflex to Titer
Test Mnemonic
NMDCSF
CPT Codes
- 86255 - QTY (1)
LOINC ®
Not available
Includes
- N-methyl-D-Aspartate Receptor Ab, CSF
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Cerebrospinal fluid (CSF) | Sterile container | Refrigerated |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.15 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
Days Performed
Sun - Sat
Turnaround Time
2 - 4 days
Methodology
| Name | Description |
|---|---|
| Semi-Quantitative Cell-Based Indirect Fluorescent Antibody |
Special Info
If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply. Contaminated, hemolyzed, or severely lipemic specimens will be rejected. This test is New York DOH approved.
Clinical Info
NMDA receptor antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response. In addition, positive results have been reported in patients with nonautoimmune phenotypes. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis. Results should be interpreted in correlation with the patient's clinical history and other laboratory findings.
Reflex Tests
The following additional test(s) may be ordered depending on results: