Mycophenolic Acid and Metabolite
Test Mnemonic
MYCMET
CPT Codes
- 80180 - QTY (1)
Includes
- Mycophenolic Acid
- Mycophenolic Acid Glucuronide
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Separate serum from cells within 2 hours of collection. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | EDTA (Lavender) | Refrigerated | Separate plasma from cells within 2 hours of collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 6 weeks |
| Refrigerated | After separation from cells: 6 weeks |
| Frozen | After separation from cells: 11 months |
Days Performed
Sun - Sat
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| Quantitative Liquid Chromatography - Tandem Mass Spectrometry |
Special Info
Timing of specimen collection: Pre-dose (trough) draw at steady state concentration. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution) are unacceptable. Whole blood will also be rejected. This test is New York DOH approved.
Clinical Info
Therapeutic monitoring for individuals taking mycophenolate. The therapeutic range is based on serum pre-dose (trough) draw at steady state concentration. A proposed therapeutic range is 1.0 - 3.5 ug/mL for a 2 g/day dose. A 3 g/day dose may have plasma concentrations up to 5.0 ug/mL. Trough concentrations between 2.0 - 4.0 ug/mL have been suggested to maximize efficacy and minimize adverse effects. Mycophenolic acid glucuronide is an inactive metabolite and a range of 35.0 - 100.0 ug/mL indicates normal metabolism. During the first two weeks of transplantation, mycophenolic acid glucuronide concentrations are typically 100 - 250 ug/mL. Adverse effects of toxicity include abdominal pain, peripheral edema, cardiac abnormalities, hypertension and electrolyte disturbances.