Plasma Carnitine Free/Total and Acylcarnitines Panel
Test Mnemonic
PCAPNL
CPT Codes
- 82379 - QTY (1)
- 82017 - QTY (1)
Includes
- Carnitine Total
- Carnitine Free (FC)
- Acylcarnitine (AC)
- AC/FC Ratio
- Interpretation
- Acetylcarnitine, C2
- Acrylylcarnitine, C3:1
- Propionylcarnitine, C3
- Formiminoglutamate, FIGLU
- Iso-/Butyrylcarnitine, C4
- Tiglylcarnitine, C5:1
- Isovaleryl-/2-Methylbutyrylcarn C5
- 3-OH-iso-/butyrylcarnitine, C4-OH
- Hexenoylcarnitine, C6:1
- Hexanoylcarnitine, C6
- 3-OH-isovalerylcarnitine, C5-OH
- Benzoylcarnitine
- Heptanoylcarnitine, C7
- 3-OH-hexanoylcarnitine, C6-OH
- Phenylacetylcarnitine
- Salicylcarnitine
- Octenoylcarnitine, C8:1
- Octanoylcarnitine, C8
- Malonylcarnitine, C3-DC
- Decadienoylcarnitine, C10:2
- Decenoylcarnitine, C10:1
- Decanoylcarnitine, C10
- Methylmalonyl-/succinylcarn, C4-DC
- 3-OH-decenoylcarnitine, C10:1-OH
- Glutarylcarnitine, C5-DC
- Dodecenoylcarnitine, C12:1
- Dodecanoylcarnitine, C12
- 3-Methylglutarylcarnitine, C6-DC
- 3-OH-dodecenoylcarnitine, C12:1-OH
- 3-OH-dodecanoylcarnitine, C12-OH
- Tetradecadienoylcarnitine, C14:2
- Tetradecenoylcarnitine, C14:1
- Tetradecanoylcarnitine, C14
- Octanedioylcarnitine, C8-DC
- 3-OH-tetradecenoylcarnitine C14:1OH
- 3-OH-tetradecanoylcarnitine, C14-OH
- Hexadecenoylcarnitine, C16:1
- Hexadecanoylcarnitine, C16
- 3-OH-hexadecenoylcarnitine,C16:1-OH
- 3-OH-hexadecanoylcarnitine, C16-OH
- Octadecadienoylcarnitine, C18:2
- Octadecenoylcarnitine, C18:1
- Octadecanoylcarnitine, C18
- Dodecanedioylcarnitine, C12-DC
- 3-OH-octadecadienoylcarn, C18:2-OH
- 3-OH-octadecenoylcarnitine C18:1-OH
- 3-OH-octadecanoylcarnitine, C18-OH
- Comment (ACRN)
- Free L-carnitine
- Total L-carnitine
- Esterified Carnitine
- Esterified Carnitine / Free Carnitine Ratio
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | Green NaHep NOGEL | Frozen | Multiple specimen tubes must be collected for this panel. This tube is for test: Carnitine Free & Total, Plasma (CARNPL). Collect specimen just prior to a scheduled meal or feeding. Patient age is required. Centrifuge and transfer the plasma to a plastic CCL tube within 2 hours of collection and freeze. | |
| 0.1 mL | Plasma | Sodium heparin (Green) | Frozen | Multiple specimen tubes must be collected for this panel. This tube is for test: Acylcarnitines, Quantitative, Plasma (ACRNPL). Collect specimen just prior to a scheduled meal or feeding. Patient age is required. Centrifuge and aliquot plasma into standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | Red Plain | Frozen | Multiple specimen tubes must be collected for this panel. This tube is for test: Carnitine Free & Total, Plasma (CARNPL). Collect specimen just prior to a scheduled meal or feeding. Patient age is required. Centrifuge and transfer the serum to a plastic CCL tube within 2 hours of collection and freeze. | |
| 1 mL | Plasma | Green LiHep Nogel | Frozen | Multiple specimen tubes must be collected for this panel. This tube is for test: Carnitine Free & Total, Plasma (CARNPL). Collect specimen just prior to a scheduled meal or feeding. Patient age is required. Centrifuge and transfer the plasma to a plastic CCL tube within 2 hours of collection and freeze. | |
| 1 mL | Plasma | Mint PST LiHep | Frozen | Multiple specimen tubes must be collected for this panel. This tube is for test: Carnitine Free & Total, Plasma (CARNPL). Collect specimen just prior to a scheduled meal or feeding. Patient age is required. Centrifuge and transfer the plasma to a plastic CCL tube within 2 hours of collection and freeze. | |
| 1 mL | Plasma | EDTA (Lavender) | Frozen | Multiple specimen tubes must be collected for this panel. This tube is for test: Carnitine Free & Total, Plasma (CARNPL). Collect specimen just prior to a scheduled meal or feeding. Patient age is required. Centrifuge and transfer the plasma to a plastic CCL tube within 2 hours of collection and freeze. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| Variable | The aliquot for Carnitine Free & Total, Plasma (CARNPL) must have a minimum volume of 0.2 mL. The aliquot for Acylcarnitines, Quantitative, Plasma (ACRNPL) must have a minimum of 0.04 mL. |
Stability
| Environmental Condition | Description |
|---|---|
| Frozen | After separation from cells: 60 days |
| Refrigerated | After separation from cells: 21 days |
| Ambient | After separation from cells: 24 hours |
Days Performed
Mon - Fri
Turnaround Time
Refer to individual components
Methodology
| Name | Description |
|---|---|
| Flow Injection Analysis-Tandem Mass Spectrometry (FIA-MS/MS) | |
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Special Info
Performing Labs: Special Chemistry, Client Services - Vendor Mayo. Indicate patient fasting hours when possible. Refer to individual tests Carnitine Free & Total, Plasma (CARNPL) and Acylcarnitines, Quantitative, Plasma (ACRNPL). Carnitine, fish oil, and omega-3 supplements affect test results; indicate supplement use on the requisition.
Clinical Info
This test is useful in the evaluation of individuals at risk for a deficiency of free carnitine, which may occur during treatment with valproate, in persons receiving chronic renal dialysis, and in some forms of malnourishment. When combined with the profile of plasma acylcarnitine species, useful in the diagnostic evaluation of individuals suspected of having a disorder of mitochondrial fatty acid beta-oxidation and many genetic disorders of organic acid metabolism. It is also useful for diagnosis of fatty acid oxidation disorders and several organic acidurias, as well as evaluating treatment during follow-up of patients with fatty acid beta-oxidation disorders and several organic acidurias.