FISH for IGH/MYC/CEP8 Tissue
Test Mnemonic
T814
CPT Codes
- 88377 - QTY (1)
Aliases
- FISH for t(8;14)
Includes
- LSI 8q24.1
- LSI 14q32.33
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Slide (s), unstained | Clean container | Ambient | 4 μm tissue sections on electrostatically charged slides. Tissue must be formalin fixed. Samples must not be fixed in Prefer or B5. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Blocks and slides should be transported at ambient temperature. |
Days Performed
5 days per week
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Special Info
4 μm tissue sections on electrostatically charged slides. Tissue must be formalin fixed. Samples must not be fixed in Prefer or B5. Tissue block containing representative tumor.
Clinical Info
Interphase FISH analysis utilizing a three color, dual fusion probe set specific to the MYC gene at 8q24.1 and the IGH gene at 14q32.33, in conjunction with the centromere of chromosomes 8. The t(8;14) rearrangement may be seen in Burkitt lymphoma and double hit B-cell lymphomas. If no cells are available for analysis, no analysis charges will be incurred.