Aquaporin-4 Receptor Antibody, IgG by CBA-IFA with Reflex to Titer, Serum




Test Mnemonic

NMOIFA

CPT Codes

  • 86052 - QTY (1)

Aliases

  • Neuromyelitis Optica IgG
  • NMO-IgG

Includes

  • Neuromyelitis Optica/AQP4-IgG, Serum

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumSST (Gold) RefrigeratedCentrifuge and transfer serum into standard aliquot tube.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumNo additive (Red) RefrigeratedCentrifuge and transfer serum into standard aliquot tube.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.15 mL     

Stability

Environmental Condition Description
Refrigerated2 weeks
Frozen1 year
Ambient48 hours

Days Performed

Mon, Wed, Fri

Turnaround Time

2 - 7 days

Methodology

Name Description
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody 

Reference Range

Special Info

If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply. Contaminated specimens are unacceptable. This test is New York DOH approved.

Clinical Info

This test is useful in the initial evaluation of neuromyelitis optica (NMO) spectrum disorders. NMO commonly presents with optic neuritis or longitudinally extensive transverse myelitis. Approximately 75% of patients with NMO have antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.