Clobazam




Test Mnemonic

CLOBAZ

CPT Codes

  • 80339 - QTY (1)
  • G0480 - QTY (1)

Aliases

  • Desmethylclobazam
  • N-desmethylclobazam
  • Norclobazam

Performing Laboratory

Mayo Clinic Dpt of Lab Med & Pathology


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mLSerumNo additive (Red) RefrigeratedDraw specimen immediately before next scheduled dose; trough specimens recommended as therapeutic ranges are based on trough collections. Centrifuge within 2 hours of collection and transfer serum into standard plastic aliquot tube. Serum gel tube is not acceptable.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.35 mL     

Stability

Environmental Condition Description
Ambient28 days
Refrigerated28 days
Frozen28 days

Days Performed

Tue, Thu

Turnaround Time

2 - 6 days

Methodology

Name Description
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) 

Reference Range

Clobazam
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal30 - 300ng/mL
N - desmethylclobazam
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal300 - 3000ng/mL

Special Info

Do not draw serum separator tubes. Draw specimen immediately before next scheduled dose. Trough specimens are recommended as therapeutic ranges are based on specimens drawn immediately before the next dose. This test is available for New York state.

Clinical Info

Useful for monitoring clobazam therapy. The results of this test should be interpreted in conjunction with the patient’s physical signs, symptoms, and other laboratory test results. Most individuals display optimal response to clobazam when serum levels of clobazam are between 30 - 300 ng/mL and n-desmethylclobazam are between 300 - 3000 ng/mL. When cloabzam levels are > 500 ng/mL or n-desmethylclobazam levels are > 5000 ng/mL, risk of toxicity is increased. Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range. Therefore, interpretation should include clinical evaluation.