CNS Demyelinating Disease Evaluation, Serum
Test Mnemonic
CDS1SE
CPT Codes
- 86053 - QTY (1)
- 86363 - QTY (1)
Aliases
- ADEM
- AQP4
- Aquaporin
- MOG
- NMO
- Optic Neuritis Antibody
- Transverse Myelitis Antibody
- Vision Loss Antibody
Includes
- NMO/AQP4 FACS, S
- MOG FACS, S
- CNS Demyelinating Disease Interp, S
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | No additive (Red) | Refrigerated | Draw 2 tubes to ensure adequate serum volume. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | SST (Gold) | Refrigerated | Draw 2 tubes to ensure adequate serum volume. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 28 days |
| Frozen | 28 days |
| Ambient | 72 hours |
Days Performed
Mon, Tue, Thu
Turnaround Time
8 - 11 days
Methodology
| Name | Description |
|---|---|
| Fluorescent Activated Cell Sorting Assay (FACS) |
Special Info
Draw 2 tubes to ensure adequate serum volume. When the results of this assay require further evaluation of myelin oligodendrocyte glycoprotein (MOG-IgG1), the MOG-IgG1 titer will be performed at an additional cost. When the results of this assay require further evaluation of neuromyelitis optica (NMO)/Aquaporin-4-IgG, the neuromyelitis optica (NMO)/aquaporin-4-IgG titer will be performed at an additional charge. New York State approved. Grossly hemolyzed, lipemic or icteric specimens will be rejected.
Clinical Info
Diagnosis of inflammatory demyelinating diseases (IDDs) with similar phenotype to neuromyelitis optica spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis. Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy. Diagnosis of neuromyelitis optica (NMO). Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease. Diagnosis of ADEM. Prediction of a relapsing disease course. Aquaporin-4 (AQP4)-IgG and myelin oligodendrocyte glycoprotein (MOG)-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).