Cytomegalovirus Antiviral Drug Resistance by Sequencing




Test Mnemonic

CYTSEQ

CPT Codes

  • 87910 - QTY (1)
  • 87900 - QTY (1)

Aliases

  • CMV Foscarnet Resistance
  • CMV Resistance Genotype
  • CMV Letermovir Resistance
  • CMV Maribavir Resistance
  • CMV UL27
  • CMV UL56
  • CMV UL54
  • CMV UL97
  • CMV Cidofovir Resistance
  • CMV Ganciclovir Resistance

Includes

  • CMV Drug Resistance by NGS, 5 Drugs (Ganciclovir, Foscarnet, Cidofovir, Maribavir, Letermovir)

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
3 mLPlasmaEDTA (Lavender) FrozenDraw 2 tubes to ensure adequate volume. Separate plasma from cells within 8 hours of collection. Transfer 3 mL plasma into a standard aliquot tube. Submit most recent viral load and test date, if available.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
3 mLPlasmaEDTA PPT (White) FrozenDraw 2 tubes to ensure adequate volume. Separate plasma from cells within 8 hours of collection. Transfer 3 mL plasma into a standard aliquot tube. Submit most recent viral load and test date, if available.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2.5 mL     

Stability

Environmental Condition Description
FrozenAfter separation from cells: 1 month
RefrigeratedAfter separation from cells: 72 hours
AmbientAfter separation from cells: 8 hours

Days Performed

Sun - Sat

Turnaround Time

4 - 10 days

Methodology

Name Description
Massive Parallel Sequencing 

Special Info

Please submit most recent viral load and test date, if available. Heparinized specimens and serum are unacceptable.

Clinical Info

Provides antiviral susceptibility information for ganciclovir, foscarnet, cidofovir, maribavir, and letermovir. Intended for patients with viral load >2.6 log IU/mL.

Clinical Limitation

This test may be unsuccessful if the plasma CMV DNA viral load is less than 2.6 log IU/mL.