FISH for FGFR1 Blood




Test Mnemonic

FGFR1F

CPT Codes

  • 88271 - QTY (2)
  • 88275 - QTY (1)
  • 88291 - QTY (1)
  • 88237 - QTY (1)

Performing Laboratory

n/a


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
5 - 7 mLBlood, peripheralEDTA (Lavender)AmbientAmbient 

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
5 - 7 mLBlood, peripheralSodium heparin (Green)AmbientAmbient 

Stability

Environmental Condition Description
Ambient48 hours
RefrigeratedAcceptable
FrozenNot acceptable

Days Performed

3 days per week

Turnaround Time

5 - 7 days

Methodology

Name Description
Fluorescent In-Situ Hybridization (FISH) 

Reference Range

FISH for FGFR1
Sex Age From Age To Type Range Range Unit
       Negative for FGFR1 rearrangement 

Clinical Info

This assay employs a break-apart probe to detect rearrangements of the FGFR1 locus on chromosome 8p11. Myeloid neoplasms with FGFR1 rearrangements are often associated with eosinophilia and represent a distinct clinicopathologic entity in the WHO classification of hematolymphoid neoplasms. This assay is useful for the evaluation of unexplained eosinophilia and to assist in the diagnosis and classification of myeloproliferative neoplasms.