FISH for FGFR1 Blood
Test Mnemonic
FGFR1F
CPT Codes
- 88271 - QTY (2)
- 88275 - QTY (1)
- 88291 - QTY (1)
- 88237 - QTY (1)
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 - 7 mL | Blood, peripheral | EDTA (Lavender) | Ambient | Ambient |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 - 7 mL | Blood, peripheral | Sodium heparin (Green) | Ambient | Ambient |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 48 hours |
| Refrigerated | Acceptable |
| Frozen | Not acceptable |
Days Performed
3 days per week
Turnaround Time
5 - 7 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Reference Range
| FISH for FGFR1 | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative for FGFR1 rearrangement |
Clinical Info
This assay employs a break-apart probe to detect rearrangements of the FGFR1 locus on chromosome 8p11. Myeloid neoplasms with FGFR1 rearrangements are often associated with eosinophilia and represent a distinct clinicopathologic entity in the WHO classification of hematolymphoid neoplasms. This assay is useful for the evaluation of unexplained eosinophilia and to assist in the diagnosis and classification of myeloproliferative neoplasms.