Human Anti-Mouse IgG Abs
Test Mnemonic
MOUABS
CPT Codes
- 83520 - QTY (1)
LOINC ®
14975-7
Aliases
- HAMA
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Frozen | Do not use serum separator tubes. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 1 day |
| Frozen | 21 days |
Days Performed
Varies
Turnaround Time
8 - 18 days
Methodology
| Name | Description |
|---|---|
| Enzyme-Linked Immunosorbent Assay (ELISA) |
Reference Range
Special Info
Do not use serum separator tubes.
Clinical Info
The human antimouse antibodies (HAMA) direct ELISA test is intended for the determination of IgG subclass of isotypic HAMA in human serum. HAMA have been reported to give false positive results in two-site immunometric assays that utilize murine (mouse) monoclonal IgG. HAMA reactivity has been detected in approximately 9% of a normal population without known exposure to murine IgG. Such responses may be due to polyclonal rheumatoid factors, heterophilic antibodies, dietary, or other exposure. Therapeutic use of murine monoclonal antibodies (IgG) or their fragments either unmodified or conjugated to drugs, toxins or radionucleotides may induce immune response directed against the same IgG and produce a significant level of HAMA in serum. Circulating levels of HAMA can bind to the injected IgG and reduce the efficacy of the antibody therapy. HAMA also can cause anaphylactic complications to subsequent administration of murine monoclonal IgG.