Hyperoxaluria, Urine | Cleveland Clinic Laboratories

Hyperoxaluria, Urine Print

Test Mnemonic

UHYPER

CPT Codes

82542 - QTY (1)

Includes

Glycolate
Glycerate
Oxalate
Interpretation
4-Hydroxy-2-Oxoglutarate

Performing Laboratory

Mayo Clinic Dpt of Lab Med & Pathology

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
10 mL	Urine, random	Clean container		Frozen	Overnight fast is required: 1) Have patient discard the first-morning void. 2) Collect specimen within 2 hours of first-morning void while patient continues to fast. Fluids are allowed. 3) Freeze the specimen immediately.

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
1.1 mL

Stability

Environmental Condition	Description
Frozen	90 days
Ambient	Unacceptable
Refrigerated	14 days

Days Performed

Varies; 2 times per month

Turnaround Time

15-31 days

Methodology

Name	Description
GC-MS Stable Isotope Dilution Analysis

Reference Range

4-Hydroxy-2-Oxoglutarate (HOG)
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	< or = 10	mg/g crt
Glycerate
Sex	Age From	Age To	Type	Range	Range Unit
	Days	31 Days	Normal	< or = 75	mg/g crt
	5 Years	10 Years	Normal	< or = 55	mg/g crt
	11 Years	99 Years	Normal	< or = 25	mg/g crt
				32 Days - 4 Years: < or = 125 mg/g crt
Glycolate
Sex	Age From	Age To	Type	Range	Range Unit
	Years	17 Years	Normal	< or = 75	mg/g crt
	18 Years	99 Years	Normal	< or = 50	mg/g crt
Oxalate
Sex	Age From	Age To	Type	Range	Range Unit
	Months	6 Months	Normal	< or = 400	mg/g crt
	2 Years	6 Years	Normal	< or = 150	mg/g crt
	7 Years	10 Years	Normal	< or = 100	mg/g crt
	11 Years	99 Years	Normal	< or = 75	mg/g crt
				7 Months - 1 Year: < or = 300 mg/g crt

Special Info

Informed consent is required for patients residing in New York State. Specimens with preservatives will be rejected.

Clinical Info

Increased concentrations of oxalate and glycolate indicate type 1 hyperoxaluria. Increased concentrations of oxalate and glycerate indicate type 2 hyperoxaluria. Increased concentrations of oxalate and 4-hydroxy-2-oxoglutarate indicate type 3 hyperoxaluria. Increased concentrations of oxalate with normal concentrations of glycolate, glycerate, and 4-hydroxy-2-oxoglutarate indicate secondary hyperoxaluria.