Hypersensitivity Pneumonitis Evaluation
Test Mnemonic
HYPNE2
CPT Codes
- 86003 - QTY (1)
- 86005 - QTY (1)
- 86606 - QTY (5)
- 86331 - QTY (5)
Aliases
- Farmer's Lung
Includes
- A. fumigatus #1 Ab, Precipitin
- A. fumigatus #6 Ab, Precipitin
- A. pullulans Ab, Precipitin
- Pigeon Serum Ab, Precipitin
- M. faeni Ab, Precipitin
- A. flavus Ab, Precipitin
- A. fumigatus #2 Ab, Precipitin
- A. fumigatus #3 Ab, Precipitin
- S. viridis Ab, Precipitin
- T. candidus Ab, Precipitin
- Allergen, Fungi/Mold, Phoma betae IgE
- Allergen, Animal, Feather Mix IgE
- Allergen, Interp, Immunocap Score IgE
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection. Transfer 2.5 mL serum to two aliquot tubes. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1.6 mL | Minimum: 0.8 mL per aliquot tube |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 48 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 1 year (avoid repeated freeze/thaw cycles) |
Days Performed
Sun - Sat
Turnaround Time
4 - 8 days
Methodology
| Name | Description |
|---|---|
| Immunodiffusion (ID) | |
| Quantitative ImmunoCAP Fluorescent Enzyme Immunoassay |
Special Info
Contaminated, hemolyzed, or severely lipemic specimens will be rejected. This test is New York state approved.
Clinical Info
This test is used to evaluate patients suspected of having hypersensitivity pneumonitis induced by exposure. Allergen results of 0.10-0.34 kU/L are intended for specialist use as the clinical relevance is undetermined. Even though increasing ranges are reflective of increasing concentrations of allergen-specific IgE, these concentrations may not correlate with the degree of clinical response or skin testing results when challenged with a specific allergen. The correlation of allergy laboratory results with clinical history and in vivo reactivity to specific allergens is essential. A negative test may not rule out clinical allergy or even anaphylaxis.