Oxycodone and Metabolite, Serum




Test Mnemonic

OXYC

CPT Codes

  • 80365 - QTY (1)
  • G0480 - QTY (1)

LOINC ®

3893-5

Aliases

  • Oxycodone and Metabolite, Quantitative
  • Oxycontin
  • Percocet

Includes

  • Oxycodone
  • Oxymorphone

Performing Laboratory

Quest Diagnostics (Specialty)


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
5 mLSerumNo additive (Red) RefrigeratedDo not use serum separator tubes.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
3 mL     

Stability

Environmental Condition Description
Ambient7 days
Refrigerated7 days
Frozen7 days

Days Performed

Mon, Wed, Fri

Turnaround Time

3 - 5 days

Methodology

Name Description
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) 

Reference Range

Oxycodone
Sex Age From Age To Type Range Range Unit
       Range: 10 - 100 ng/mL 
Oxymorphone
Sex Age From Age To Type Range Range Unit
       Reference range not established 

Special Info

Do not use serum separator tubes.

Clinical Info

For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy. Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 29, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg, respectively. Oxymorphone is a minor but active metabolite of Oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.