Protein S Clottable
Test Mnemonic
PRSCLT
CPT Codes
- 85306 - QTY (1)
LOINC ®
27822-6
Aliases
- Pro S Functional
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | Sodium citrate (Lt. Blue) | Frozen |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Days Performed
Mon - Fri
Turnaround Time
1 - 3 days
Methodology
| Name | Description |
|---|---|
| Clotting Assay |
Reference Range
| Protein S Clottable | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Days | 1 Days | Normal | 14-90 | % | 2 Days | 5 Days | Normal | 14-90 | % | 6 Days | 30 Days | Normal | 14-90 | % | 1 Months | 3 Months | Normal | 49-114 | % | 4 Months | 11 Months | Normal | 50-116 | % | 1 Years | 5 Years | Normal | 43-167 | % | 6 Years | 10 Years | Normal | 45-150 | % | 11 Years | 16 Years | Normal | 53-133 | % | 17 Years | 999 Years | Normal | 59-152 | % |
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. If protein S clottable is decreased, suggest ordering factor VIII, APC - R and protein S immunologic.
Clinical Info
For use in the evaluation of hypercoagulable state due to congenital or acquired protein S deficiency. This is a functional assay which detects the amount of Protein S in plasma. Coumadin will lower protein S levels. Elevated factor VIII levels (>250%) and APC resistance (factor V Leiden) can lower protein S clottable. High heparin concentration (> 1 unit/ mL) and lupus anticoagulant can falsely elevate protein S clottable.