Prothrombin Antibody, IgG




Test Mnemonic

PTABGM

CPT Codes

  • 86849 - QTY (1)

Aliases

  • Antiprothrombin Antibodies
  • Anti-Prothrombin Antibodies
  • aPT Antibodies
  • Prothrombin Antibody, IgG

Includes

  • Prothrombin Antibody, IgG

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mLSerumSST (Gold) RefrigeratedSeparate serum from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mLPlasmaSodium citrate (Lt. Blue) RefrigeratedSeparate plasma from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.3 mL     

Stability

Environmental Condition Description
AmbientAfter separation from cells: 48 hours
RefrigeratedAfter separation from cells: 2 weeks
FrozenAfter separation from cells: 1 year

Days Performed

Mon

Turnaround Time

2 - 9 days

Methodology

Name Description
Semi Quantitative Enzyme Linked Immunosorbent Assay 

Reference Range

Prothrombin Ab, IgG
Sex Age From Age To Type Range Range Unit
       Normal< 20Units

Special Info

Preferred second-line testing for strong suspicion of seronegative antiphospholipid syndrome (APS). Order incrementally or concurrently with other non-criteria antiphospholipid antibody tests. Severely hemolyzed or icteric specimens will be rejected. This test is New York state approved.

Clinical Info

IgG antibodies to prothrombin may be a risk factor for either venous or arterial thrombosis in antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies. If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies. Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.