Urine Free Cortisol by LC-MS/MS
Test Mnemonic
UFRCRT
CPT Codes
- 82530 - QTY (1)
- 82530 - QTY (1)
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, 24-hour (well-mixed) | Clean container | Refrigerate during collection. | Refrigerated |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, random | Clean container | Refrigerated |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 2 weeks |
| Frozen | 6 months |
Days Performed
Sun - Sat
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Free Cortisol | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| 3 Years | 8 Years | Normal | < or = 18 | ug/24 hrs | 9 Years | 12 Years | Normal | < or = 37 | ug/24 hrs | 13 Years | 17 Years | Normal | < or = 56 | ug/24 hrs | Female | 18 Years | 99 Years | Normal | < or = 45 | ug/24 hrs | Male | 18 Years | 99 Years | Normal | < or = 60 | ug/24 hrs |
| Free Urine Cortisol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Female | Normal | Pregnancy: <59 | ug/g crt | Female | Normal | Prepubertal: <25 | ug/g crt | Female | 18 Years | 99 Years | Normal | < 24 | ug/g crt | Male | Normal | Prepubertal: <25 | ug/g crt | Male | 18 Years | 99 Years | Normal | < 32 | ug/g crt |
Special Info
Indicate period and volume on requisition. Acidified specimens and specimens with preservatives are unacceptable.
Clinical Info
The optimal specimen for this testing is a 24-hour urine collection. Mass per day calculations are not reported for the following specimen types: a random collection, a collection with duration of less than 20 hours, a collection with duration greater than 28 hours, or a collection with total volume less than 400 mL or greater than 5000 mL. Ratios to creatinine may be useful for these evaluations. Baseline urinary free cortisol excretions less than 5 ug/day may be consistent with adrenal insufficiency.