PM-Scl-100 Antibody, IgG by Immunoblot
Test Mnemonic
PM1AB
CPT Codes
- 86235 - QTY (1)
LOINC ®
61120-2
Aliases
- PM-1 Antibody
- Polymyositis Associated Antibody
Includes
- PM/Scl 100 Antibody, IgG
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Transfer 1 mL serum into standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 48 hours |
| Frozen | After separation from cells: 1 month (avoid repeated freeze/thaw cycles) |
| Refrigerated | After separation from cells: 14 days |
Days Performed
Tue, Thu, Sat
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| Immunoblot (IB), Qualitative |
Reference Range
| PM-Scl Antibody | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative |
Special Info
Contaminated, hemolyzed, or severely lipemic specimens will be rejected. This test is New York DOH approved.
Clinical Info
The presence of PM/Scl-100 IgG antibody along with a positive ANA IFA nucleolar pattern is associated with connective tissue diseases such as polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), and polymyositis/systemic sclerosis overlap syndrome. The clinical relevance of PM/Scl-100 IgG antibody with a negative ANA IFA nucleolar pattern is unknown. PM/Scl-100 is the main target epitope of the PM/Scl complex, although antibodies to other targets not detected by this assay may occur.