Hematopathology Consultative Services

Pathology Consultative Services

Hematopathology Consultative Services

Our test menu combines the state-of-the-art laboratory diagnostics required in modern hematology practice with a foundation of expert consultation for bone marrow biopsies and lymphoid tissues.

A wide range of offerings in flow cytometry, molecular hematology, immunohistochemistry, and cytogenetic karyotyping help answer today’s complex hematology questions.

The added support of our subspecialty-trained hematopathologists provides interpretations to our clients with meaningful clinical context. Our services are designed to be flexible based on the needs of each client and each case, from performing a single test to providing full-service consultation.

Bone Marrow Consultation

Bone marrow aspirates and biopsies are performed in the evaluation of patients with suspected hematologic disease or hematolymphoid disorders.

The best value for the patient is achieved when the treating physician provides pertinent clinical information, an adequate specimen is obtained, and samples are packed and shipped properly. Our Bone Marrow Biopsy Consultation Kit provides the necessary materials to ensure specimen integrity during shipment to our laboratories.

In some cases, additional studies may be performed on this material, such as cytochemistry, immunohistochemistry, or molecular, at the discretion of the pathologist.

Flow cytometric immunophenotyping services are available on bone marrow samples for the evaluation of suspected hematologic malignancy. This includes a morphologic review of submitted stained or unstained aspirate smears, along with four-color flow cytometric analysis, and interpretation by a staff hematopathologist. This review includes an initial morphologic evaluation to determine the appropriateness of the panel requested.

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Cleveland Clinic Laboratories offers a full range of expert consultative services for bone marrow evaluation and interpretation.

  • Evaluation of Prepared Peripheral Blood Smears
  • Bone Marrow Aspirate Smears
  • Touch Imprints
  • Core Biopsies
  • Clot Sections (if available)
  • Full Morphologic Interpretation of Bone Marrow Specimens

Lymphoma Consultation

Cleveland Clinic Laboratories offers comprehensive, expert consultative services for the evaluation of lymphoproliferative disorders.

Flow Cytometric Immunophenotyping with Histopathologic Evaluation

Clients may send fresh tissue in tissue culture medium for flow cytometric immunophenotyping. When routinely processed tissue is available, histologic slides and paraffin blocks are forwarded for evaluation and diagnosis.

Refer to flow cytometry and surgical pathology in the Test Directory for more information.

Histopathologic Evaluation, Paraffin-Embedded Tissues

Specimens (slides and tissue blocks) may be sent for diagnostic consultation. Ancillary studies, such as immunohistochemistry and molecular diagnostics, will be performed if required.

Refer to surgical pathology in the Test Directory for more information.

Flow Cytometry Only

Specimens may be sent fresh in tissue culture medium for flow cytometric immunophenotyping with interpretation by a staff hematopathologist.

A full range of ancillary techniques—including flow cytometric immunophenotyping, immunohistochemistry, and molecular diagnostics—is available to healthcare providers.

Flow Cytometry

The Flow Cytometry Laboratory provides a wide range of immunophenotyping services supported by expert hematopathology staff and personnel.

Services include the assessment of leukemias and lymphomas, lymphocyte subsetting for immunodeficiency states and transplantation immunosuppression status, hematopoietic stem cell enumeration, screening for paroxysmal nocturnal hemoglobinuria, and human leukocyte antigen (HLA) B27 testing.

Available Services

Blood samples are assessed for lymphocyte subsetting in whole blood, which may be performed as part of the initial diagnosis or in the setting of therapeutic monitoring.

HLA-B27 testing is used to identify the B27 protein on the surface of white cells in whole blood. The presence of this protein is strongly associated with several rheumatic disorders and ankylosing spondylitis (AS), a chronic inflammatory disease of the musculoskeletal system.

Blood, bone marrow, body fluid, and tissue samples suspected of being involved by leukemia or lymphoma undergo morphologic review and multiparameter flow cytometric immunophenotyping using antibody panels specifically designed to detect and characterize hematologic malignancies. Hematopathologists interpret the results in the context of morphologic findings and provide information on clinical-pathologic correlations to assist clients in accurate and timely diagnosis.

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Fast Results

Turnaround for most pathology cases is within 48 hours.

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Expert Consultation

Our staff is available for consultation during any stage of diagnosis or treatment.

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Flexible Billing Solutions

Options include third-party and client billing that can be customized to your needs.

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Reporting Options

Concise, in-depth reports are available for each consultation.

Hematopathology Staff

Our pathologists are nationally and internationally reputed for their diagnostic and academic excellence.

Staff members at Cleveland Clinic Laboratories publish extensively in leading medical journals and regularly serve on editorial boards. Our hematopathologists also routinely collaborate with clinicians in the Cleveland Clinic Taussig Cancer Institute.

Interested in Sending a Pathology Consult?

Our pathologists are nationally- and internationally-recognized experts who are widely acknowledged for their expertise in their subspecialties as well as for their contributions to research and advancements in diagnostic pathology.

James Cook, MD, PhD

James Cook, MD, PhD
Section Head, Hematopathology

Shweta Bhavsar, MD

Shweta Bhavsar, MD

David Bosler, MD

David Bosler, MD

Claudiu Cotta, MD, PhD

Claudiu Cotta, MD, PhD

Genevieve Crane, MD

Genevieve Crane, MD
Medical Director, Manual Hematology

Sherri Flax, MD

Sherri Flax, MD

Morayma Reyes Gil, MD

Morayma Reyes Gil, MD
Medical Director, Hemostasis & Thrombosis

Megan Nakashima, MD

Megan Nakashima, MD
Medical Director, Automated Hematology

Sarah Ondrejka, DO

Sarah Ondrejka, DO
Medical Director, Flow Cytometry

Anna Owczarczyk, MD, PhD

Anna Owczarczyk, MD, PhD

Ziad Peerwani, MDD

Ziad Peerwani, MD

Joyce Heesun Rogers, MD, PhD

Joyce Heesun Rogers, MD, PhD

Karl Theil, MD

Karl Theil, MD