| 6058 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
2SC (P) |
S-(2-succinyl)-cysteine |
88,342 |
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is an autosomal disorder caused by germline mutation in the fumarate hydratase (FH) gene on chromosome 1q43. HLRCC associated RCC is often aggressive with metastatic disease in 50% of pat |
| 6059 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Actin (Alpha SM) (1A-4) |
SMA, Smooth Muscle Actin |
88,342 |
Smooth muscle actin, mouse monoclonal 1A4, labels smooth muscle cells, myofibroblasts, and myoepithelial cells, and is a useful tool for the identification of leiomyomas, leiomyosarcomas, and pleomorphic adenomas. Cytoplasmic actins, which belong to the m |
| 6060 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Actin (HHF35) |
Muscle Specific Actin |
88,342 |
Muscle specific actin (MSA), a highly conserved, ubiquitous cytoskeletal protein of muscle and nonmuscle cells, exists in three isotypes (α, β, γ) that differ by their amino acid sequences and isoelectric points. Actin does not react with the α-actin of n |
| 6061 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Adenovirus (20/11 & 2/6) |
none known |
88,342 |
Adenoviruses are medium-sized (90-100 nm), non-enveloped icosohedral viruses with double-stranded DNA. More than 50 types of immunologically distinct adenoviruses can cause infections in humans. Adenoviruses are relatively resistant to common disinfectant |
| 6062 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ADH5 |
CK5/14 + p63 + CK7/18 |
88,344 |
The ADH5 (CK5/14 + p63 + CK7/18) cocktail is comprised of mouse monoclonal anti-CK5, anti-CK14, and anti-p63 antibodies and rabbit monoclonal anti-CK7 and anti-CK18 antibodies. CK5 and CK14 are high molecular weight keratins expressed in the cytoplasm of |
| 6063 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Adipophilin (BSB-91) |
PLIN2, Perilipin 2, ADRP |
88,342 |
Adipophilin (also known as PLIN2) detects expression of adipocyte differentiation-related protein (ADRP/ADFP) in sebocytes and sebaceous lesions. Adipophilin is a useful marker in the identification of intracytoplasmic lipids, seen commonly in sebaceous |
| 6064 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
AE1 & 3 (AE1/3) |
Pankeratin, Cytokeratin AE1/AE3 |
88,342 |
Keratins are a group of water-insoluble proteins that form monofilaments, a class of intermediate filament. These filaments form part of the cytoskeletal complex in epidermis and in most other epithelial tissues. Nineteen human epithelial keratins are res |
| 6065 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
AFF2 (1G13) |
ALF Transcription Elongation Factor 2 |
88,342 |
DEK::AFF2 rearranged sinonasal squamous cell carcinoma is a recently described variant of squamous cell carcinoma, notable for deceptively bland cytologic features yet aggressive clinical behavior. These tumors can occasionally be indistinguishable from o |
| 6066 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
AFP (P) |
Alpha-fetoprotein |
88,342 |
Positive results may aid in the identification of non-neoplastic and neoplastic liver disease, yolk sac tumors and mixed germ cell tumors. AFP is a 70 kDa glycoprotein containing 590 amino acid residues. Cells of the embryonic yolk sac, fetal liver, and f |
| 6067 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ALK (D5F3) |
Anaplastic lymphoma kinase, ALK Protein, CD246 |
88,342 |
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development. In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, |
| 6068 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ALK-1 (ALK-1) |
Anaplastic lymphoma kinase, ALK Protein, CD246 |
88,342 |
The antibody labels normal human ALK protein and the NPM-ALK chimeric protein, and is a useful tool for the identification of the subgroup of anaplastic large-cell lymphomas (ALCL) that are ALK positive. The wild-type anaplastic lymphoma kinase (ALK) pro |
| 6069 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
AMACR (SP116) |
Racemase, p504S |
88,342 |
AMACR (p504s) is normally negative or only very faintly expressed in normal glands of the prostate. In contrast, 80% or more of invasive adenocarcinomas show luminal cytoplasmic expression of p504S (AMACR). Immunohistochemistry for AMACR therefore assis |
| 6070 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
AMYLOID KAPPA (P) |
Kappa Free Light Chains |
88,342 |
Immunoglobulins are composed of four protein chains: two light chains (either kappa or lambda light chains), and two heavy chains, of which there are several types. These proteins are produced by the plasma cells in the bone marrow. In AL patients, these |
| 6071 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
AMYLOID LAMBDA (P) |
Lambda Free Light Chains |
88,342 |
Immunoglobulins are composed of four protein chains: two light chains (either kappa or lambda light chains), and two heavy chains, of which there are several types. These proteins are produced by the plasma cells in the bone marrow. In AL patients, these |
| 6072 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Androgen Receptor (SP107) |
AR, NR3C4 (nuclear receptor subfamily 3, group C, member 4) |
88,342 |
Androgen receptor is an intracellular protein that mediates the biological actions of physiological androgens such as testosterone and 5 α-dihydrotestosterone, which are essential for differentiation, development, and maintenance of the male reproductive |
| 6073 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Annexin A1 (MRQ-3) |
ANXA1 |
88,342 |
Annexin A1 is a monomeric, amphipathic protein containing 346 amino acids, originally purified from the peritoneal lavage of rats treated with glucocorticoids. This protein is expressed in multiple types of cells. In neutrophils and mast cells Annexin A |
| 6074 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Arginase-1 (SP156) |
ARG-1 |
88,342 |
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver accounting for an estimated 70-85% of total liver cancers worldwide. The incidence is increasing in the West due to the burden of chronic hepatitis C infection &steatoh |
| 6075 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ARID1A (EP303) |
AT-Rich Interaction Domain 1A, BAF250 |
88,342 |
The AT-Rich Interaction Domain 1A (ARID1A) is a crucial component of the SWI/SNF chromatin remodeling complex, playing a pivotal role in the regulation of gene expression. Aberrations in ARID1A expression have been documented in various malignancies, part |
| 6076 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ATRX (P) |
Alpha-thalassemia/mental retardation X-linked gene, XH2, XNP |
88,342 |
Alpha-thalassemia/mental retardation X-linked (ATRX) gene is mutated in high grade astrocytomas, as opposed to oligodendrogliomas, oligoastrocytomas and glioblastomas. This phenotype characterized by loss of function of ATRX has been called alternative l |
| 6077 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
B72.3 (TAG-72) (B72.3) |
TAG-72, Tumor associated glycoprotein 72 |
88,342 |
Tumor associated glycoprotein (TAG)-72 is a high molecular weight glycoprotein that is present on the surface of many neoplastic cells, including adenocarcinomas of the breast, colon, and lung. TAG-72 is found in lung adenocarcinoma and is absent in mesot |
| 6078 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BAP1 (C4) |
BRCA1-Associated Protein 1, ubiquitin carboxyl-terminal hydrolase BAP1, ubiquitin carboxyl-terminal hydrolase like-2 (UCHL2) |
88,342 |
BRCA-1 gene and BRCA1-associated protein 1 (BAP1) are expressed in most tissues.5 BAP1 functions as a deubiquitinase. By removing ubiquitin, BAP1 helps regulate the function of many proteins involved in diverse cellular processes. The BAP1 protein is thou |
| 6079 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BCL-2 (124) |
B cell lymphoma 2 |
88,342 |
The assessment of bcl-2 expression by immunohistochemical (IHC) staining is useful in the assessment of hematologic neoplasms including follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphomas. Anti-BCL2 has shown consistent negative rea |
| 6080 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BCL2 EP36 (EP36) |
B cell lymphoma 2 |
88,342 |
The Bcl-2 family of proteins regulates apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c. Over-expression o |
| 6081 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BCL-6 (LN22) |
B cell lymphoma 6 protein |
88,342 |
BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. In normal tissue these antibodies have strong nuclear staining for a subset of B-lymphocytes, mostly located in germinal centers (GC). BCL6 antibodies s |
| 6082 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
beta-Amyloid (RBT-A4) |
Amyloid beta-protein, Amyloid β-peptide, Aβ, βA4 protein |
88,342 |
Detection of neurofibrillary tangles and amyloid pathology are required for the diagnosis of Alzheimer’s disease. Both tangles and plaques may be detected by histochemical stains or by immunohistochemistry. Guidelines published by the National Institute |
| 6083 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
beta-Catenin (14) |
Catenin-beta-1 |
88,342 |
Β-catenin is part of the Wnt signaling pathway - a highly conserved pathway with a critical role in embryonic development, carcinogenesis, and epithelial-to-mesenchymal transition. On Wnt activation, β-catenin is translocated from the membrane to the cyt |
| 6084 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BOB-1 (SP92) |
OBF-1, Oct binding factor-1 |
88,342 |
BOB.1, also known as Oct-binding factor-1, is a B-cell transcription factor. In normal tissues, germinal center B-cells strongly express nuclear BOB.1 with weaker staining seen in non-germinal center B-cells. Immunohistochemical staining for BOB.1, in c |
| 6085 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BRACHYURY (1H9A2) |
Bry, TBXT, T-Box Transcription Factor T |
88,342 |
Brachyury is involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. When bound to the T site, activates gene transcription. Genetic variations are associated with susceptibility to neural tube defects and |
| 6086 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
BRAF (VE-1) |
BRAF mutated V600E |
88,342 |
BRAF is the product of a proto-oncogene located on chromosome 7q34. It is a serine/threonine kinase that plays a role in the MAP/ERK signaling cascade. Mutations involving BRAF have been described in numerous neoplasms, BRAF V600E mutation being the mos |
| 6087 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
C4d (P) |
Complement 4d |
88,342 |
Complement split product C4d is generated during activation of classic complement pathway. C4d is a stable product that stays bound to the target for weeks facilitating detection on sampled tissues. The protein is expressed as a single chain precursor w |
| 6088 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Calcitonin (SP17) |
CT, thyrocalcitonin |
88,342 |
The antibody labels calcitonin-producing C-cells. Antibodies to calcitonin have been shown to aid in the classification of MTC. Calcitonin (CT) is a 32 amino acid peptide hormone derived from a precursor consisting of 136 amino acids and an N-terminal l |
| 6089 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Calponin (CALP) |
Calponin-1, Basic calponin |
88,342 |
Calponin is a calmodulin, F-actin and tropomyosin binding protein which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differenti |
| 6090 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CALRETICULIN (CAL2) |
CALR |
88,342 |
CALR mutations are detectable in 67% of essential thrombocythemia (ET) and 88% of primary myelofibrosis (PMF) cases negative for mutations involving JAK2 or MPL genes. Myelodysplastic syndromes overlap neoplasms, chronic myelogenous leukemia or reactive |
| 6091 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Calretinin (SP65) |
Calbindin |
88,342 |
Calretinin, a calcium-binding protein with a molecular weight of 29 kD, is a member of the large family of EF-hand proteins that also include S-100 protein. EF-hand proteins are characterized by a helix-loop-helix fold that acts as the calcium-binding sit |
| 6092 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CAM 5.2 (CAM5.2) |
Cytokeratin CAM5.2 |
88,342 |
Cytokeratin clone CAM5.2 has a primary reactivity with human keratin proteins that correspond to Moll’s peptides #7 and #8, Mr 48 and 52 kd respectively. Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not on stratified |
| 6093 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CAMTA 1 (P) |
Calmodulin Binding Transcription Activator 1 |
88,342 |
Epithelioid hemangioendothelioma (EHE) is a malignant vascular neoplasm with significant potential for both local recurrence and metastasis. EHE is characterized by recurrent chromosomal translocations involving the regions 1p36.3 and 3q25. In about 90% o |
| 6094 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Carbonic Anhydrase IX (EP161) |
CA9, CAIX |
88,342 |
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it is a diagnostic marker for var |
| 6095 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Cathepsin-K (3F9) |
CTSK |
88,342 |
Cathepsin K is closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Cathepsin K displays potent endoprotease activity against fibrinogen at acid pH and may play an important role in extracellu |
| 6096 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD10 (56C6) |
CALLA (common acute lymphoblastic leukemia antigen) |
88,342 |
CD10, common acute lymphoblastic leukemia antigen, is expressed by a subset of T follicular helper cells. It has a direct role in cell growth and apoptosis and has been implicated in tumor cell proliferation. CD10 expression has been reported in a variety |
| 6097 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD103 (EPR4166(2)) |
Alpha E Integrin, Human mucosal lymphocyte antigen 1 |
88,342 |
CD103 (alpha E integrin) is expressed by intraepithelial T lymphocytes in the intestine, tonsil and lung as well as some dendritic cells. CD103 is expressed by enteropathy-associated T-cell lymphomas which are thought to arise from intraepithelial lymphoc |
| 6098 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD117 (EP10) |
KIT Proto-Oncogene, Receptor Tyrosine Kinase, c-kit |
88,342 |
The antibody labels the transmembrane tyrosine kinase receptor CD117/c-kit, located in hematopoietic stem cells, melanocytes, mast cells, Cajal cells, germ cells, basal cells of skin, and mammary ductal epithelia. The antibody may be a useful tool for the |
| 6099 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD123 (7G3) |
IL-3Rα |
88,342 |
Reacts with human CD123, the 70 kD IL-3 receptor α chain (IL-3Rα), which associates with the 120-140 kD β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors and plays an imp |
| 6100 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD138 (B-A38) |
Syndecan-1 |
88,342 |
CD138 (aka syndecan-1a) protein backbone is a single chain molecule of 30.5 kDa. Five putative GAG attachment sites exist in the extracellular domain. GAG fine structure appears to reflect the cellular source of the syndecan. Expression of CD138 in human |
| 6101 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD14 (EP128) |
Leu M3 |
88,342 |
Anti-CD14 labels a 55 kDa, glycosyl-phosphatidylinositol-linked membrane protein, involved in endotoxin binding and recognition of apoptotic cells. CD14 is expressed by monocytes and dermal dendritic cells; anti-CD14 is considered to be a macrophage-deriv |
| 6102 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD15 (BRA4F1) |
Blood group antigen Lewis X |
88,342 |
CD15 (BRA4F1) reacts with human CD15 antigen present on myeloid cells, mainly granulocytes but not on B cells, T cells, monocytes, erythrocytes or platelets. It also reacts with Hodgkin's and Reed-Sternberg cells in individuals with Hodgkin's disease. |
| 6103 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD15 (MMA) |
Fucosyltransferase 4, FUT4 |
88,342 |
CONFIRM anti-CD15 (MMA) recognizes lacto-N-fucopentose III. Antibodies against CD15 normally react in a strong cell surface membrane staining pattern with granulocytes and granulocyte precursors, monocytes, a subset of tissue macrophages, and activated T- |
| 6104 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD163 (MRQ-26) |
M130 |
88,342 |
CD163 is a hemoglobin scavenger receptor with variable expression in monocytes (low affinity) and tissue macrophages (high affinity). In its soluble form, it is an anti-inflammatory molecule and is important in inflammatory states such as rheumatoid arth |
| 6105 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD19 (BT51E) |
B-Lymphocyte Surface Antigen B4 |
88,342 |
CD19 is a transmembrane glycoprotein member of the immunoglobulin superfamily. It is considered to be one of the most reliable surface markers of B cell lineage over a wide range of maturational stages. Similar to the widely used B cell marker CD20, CD19 |
| 6106 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD1a (O10) |
Leu6 |
88,342 |
CD1a is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on ce |
| 6107 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD2 (AB75) |
Lymphocyte function antigen 2 (LFA2) |
88,342 |
The CD2 antigen, also known as lymphocyte function antigen2 (LFA2), is a single chain type I transmembrane molecule of about 50 kD and consists of 351 amino acids. It plays a critical role in activation of T cells. It binds to CD58 on antigen presenting c |
| 6108 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD20 (L26) |
MS4A1 |
88,342 |
CD20 is a transmembrane, non-glycosylated protein expressed on B-cell precursors and mature B cells, but is lost following differentiation into plasma cells. In resting B cells, CD20 appears in a 33 kDa non-phosphorylated form. After mitogen stimulation, |
| 6109 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD200 (E5I9V) |
OX2 |
88,342 |
CD200 is a member of the immunoglobulin superfamily expressed in a variety of cell types including B-cell and T-cell subsets, endothelial cells, and neurons. Within B-cell non-Hodgkin lymphomas, CD200 expression has been reported in >95% of cases of chro |
| 6110 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD21 (1F8) |
CR2 |
88,342 |
CD21, or complement receptor 2 (CR2) is the receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells, and for heterogeneous nuclear ribonucleoprotein U (HNRPU). It participates in B lymphocytes activation. Genetic variations i |
| 6111 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD22(SP104) |
SIGLEC2, Sialic Acid-Binding Ig-Like Lectin 2, T-Cell Surface Antigen Leu-14 |
88,342 |
CD22 is an approximately 135 kDa transmembrane glycoprotein, which plays a role in the regulation of B-cell function. Normal CD22 expression is observed in follicular mantle and marginal zone B-cells. Expression is low on germinal center B-cells and abse |
| 6112 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD23 (BU38) |
FCER2 |
88,342 |
CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. F |
| 6113 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD25 (4C9) |
IL2RA |
88,342 |
CD25 antigen, the alpha subunit of interleukin-2 receptor, is a single-chain glycoprotein with a molecular weight of 55 kD. Following the activation of T cells interleukin-2 (IL-2) is rapidly synthesized and secreted. In response to this a subpopulation o |
| 6114 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD3 (2GV6) |
|
88,342 |
CD3 (2GV6) is a rabbit monoclonal antibody produced against a synthetic peptide from the carboxy terminal region of the CD3 epsilon chain. CD3 epsilon chain is expressed in T lymphocytes, natural killer (NK) cells, and T-cell and NK-cell neoplasms. The C |
| 6115 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD30 (Ber-H2) |
Ki-1 antigen |
88,342 |
The anti-CD30 (Ber-H2) antibody is a mouse monoclonal antibody produced against a membrane bound glycoprotein that has a molecular mass of 105-120 kD. CD30 is a member of the tumor necrosis factor superfamily which when activated results in the signaling |
| 6116 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD30 (JCM182) |
Ki-1 antigen |
88,342 |
The CD30 antigen is a single chain glycoprotein with a molecular weight of 120 kD. CD30 antigen is known to act as a receptor for a cytokine ligand, CD30L, and may also play a role in the regulation of cellular growth and transformation. CD30 antigen is r |
| 6117 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD303 (992258) |
DLEC, CLEC4C, BDCA-2, HECL, Dendritic cell lectin |
88,342 |
CD303 (blood dendritic cell antigen-2, BDCA-2) is a type II C-type lectin receptor that is selectively expressed by plasmacytoid dendritic cells and can be used as a highly specific marker for normal and neoplastic plasmacytoid dendritic cells. It can be |
| 6118 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD31 (JC/70A) |
PECAM-1, platelet/endothelial cell adhesion molecule 1 |
88,342 |
The antibody primarily labels endothelial cells, and is a useful tool for the identification of benign and malignant vascular disorders, including angiosarcomas. In addition, the antibody is valuable for the labelling of vessels when determining angiogene |
| 6119 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD33 (PWS44) |
SILEC3, gp67 |
88,342 |
Clone PWS44 is recommended for the identification of human CD33 protein in normal and neoplastic tissues. In normal tissues, clone PWS44 detected the CD33 antigen in myeloid and myelomonocytic hemopoiesis and mature macrophages; cells of the erythroid and |
| 6120 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD34 (QBEnd/10) |
Hematopoietic Progenitor Cell Antigen CD34 |
88,342 |
CD34 is a cell surface glycophosphoprotein expressed on human hematopoietic progenitor cells and can be used for identifying blast cells. CD34 is a marker for vascular endothelial cells and has been shown in literature to be highly sensitive for angiosarc |
| 6121 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD35 (EP197) |
C3b receptor (C3bR), C4bR, Complement Receptor type 1 (CR1), Immune Adherence Receptor |
88,342 |
CD35 is a type 1 single-chain cell surface membrane glycoprotein with molecular mass polymorphism due to differences in the number of short consensus repeats (SCRs) in the extracellular region and variation in glycosylation (190 kDa, 23 SCRs; 220 kDa, 30 |
| 6122 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD38 (SP194) |
ADP-RIBOSYL CYCLASE, CYCLIC ADP-RIBOSE HYDROLASE |
|
CD38, also known as ADP ribosyl cyclase 1, is a marker expressed by many hematolymphoid elements, including hematopoietic stem cells, hematogones and subsets of lymphoid cells with enzymatic and adhesion molecule features. It is also a marker of activati |
| 6123 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD4 (SP35) |
T-Cell Surface Antigen T4/Leu-3 |
88,342 |
CD4 is a single chain transmembrane glycoprotein found on the helper-inducer T-cells, representing approximately 45% of mature peripheral blood T-cell lymphocytes. It is also present on about 80% of thymocytes as well as on some monocytes. B-cells do no |
| 6124 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD43 (MT1) |
Leukosialin, gpL115, sialophorin |
88,342 |
CD43 is expressed, typically at high levels, on all leukocytes except most resting B lymphocytes. The expression on platelets is weak. CD43 is rapidly lost from lymphocyte and neutrophil surface by proteolytic shedding after activation with various stimul |
| 6125 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD44 (DF1-485) |
CD44s, ECMRIII, Hermes antigen, homing-associated cell adhesion molecule (H-CAM), and Pgp-1 |
88,342 |
CD44 is a type I transmembrane adhesion molecule with a molecular mass of 85-90 kDa. It is a glycoprotein with extensive O-linked glycosylation and 6 potential N-linked glycosylation sites. A portion of the N-terminal domain of CD44 shows homology with a |
| 6126 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD45 (2B11+PD7/26) |
Leucocyte Common Antigen (LCA), T200, Ly-5 |
88,342 |
CD45 is a transmembrane glycoprotein expressed on most nucleated cells of haematopoietic origin. CD45, encoded by a single gene mapped to chromosome 1, has various isoforms based on differential splicing of exons 4, 5 and 6. On human leucocytes, five diff |
| 6127 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD5 (SP19) |
LEU1 |
88,342 |
CD5 is a T-cell marker that also reacts with a range of neoplastic B-cells, e.g. B-cell chronic lymphocytic leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), and mantle cell lymphoma. CD5 is expressed in T lymphocyte subsets and is modulated du |
| 6128 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD56 (MRQ-42) |
Neural cell adhesion molecule (NCAM) |
88,342 |
CD56, known as neural cell adhesion molecule (NCAM), was originally identified in the nervous system and belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. Anti-CD56 recognizes two proteins of the NCAM, the basic |
| 6129 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD57 (NK-1) |
HNK-1, human natural killer-1 |
88,342 |
CD57, also known as HNK-1 (human natural killer-1), is a cell surface carbohydrate epitope expressed on terminally differentiated T-cells and subsets of natural killer (NK) cells. It has also been identified on cells of neural crest origin. Anti-CD57 is |
| 6130 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD61 (2f2) |
GPIIIa |
88,342 |
Clone 2f2 detects the CD61 antigen in megakaryocytes and platelets. It is recommended for use in detecting CD61 protein expression in a variety of normal and neoplastic tissues. |
| 6131 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD68 (KP-1) |
Macrosialin |
88,342 |
CD68 is a monocyte/macrophage marker useful in the diagnosis of myeloid sarcoma, histiocytic sarcoma, and acute myeloid leukemia. Several reagents exist including KP-1 and PG-M1. The latter has been reported by several groups to be more monocyte/macroph |
| 6132 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD68 (PG-M1) |
Macrosialin |
88,342 |
CD68 is a highly glycosylated lysosomal membrane protein with an Mr of 110 000. The CD68 protein belongs to a family of lysosomal glycoprotein (LGP)/plasma membrane shuttling proteins that play a role in endocytosis and/or lysosomal trafficking. CD68 is e |
| 6133 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD7 (SP94) |
Tp41 |
88,342 |
The CD7 molecule is a membrane-bound glycoprotein of 40 kDa, and is the earliest Tcell specific antigen to be expressed in lymphocytes. CD7 is expressed in the majority of thymocytes, peripheral blood T-cells and natural killer cells. Used in combination |
| 6134 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD71 (10F11) |
Transferrin receptor-1 |
88,342 |
CD71 (transferrin receptor-1) is an integral membrane glycoprotein that mediates cellular uptake of transferrin-iron complexes. CD71 has been found to be highly expressed on placental syncytiotrophoblasts, myocytes, basal keratinocytes, hepatocytes, endoc |
| 6135 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD79a (JCB117) |
Ig-α |
88,342 |
The antibody labels B cells and is a useful tool for the identification of B-cell neoplasms of all maturation stages. CD79 is a disulphide-linked transmembrane heterodimer with a molecular mass of 82-95 kDa belonging to the immunoglobulin superfamily. It |
| 6136 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD8 (SP239) |
|
88,342 |
CD8 is a heterodimeric, disulphide linked, transmembrane glycoprotein found on the cytotoxic-suppressor T cell subset representing 30-35% of peripheral blood T cell lymphocytes, but not on B cell lymphocytes. CD8 is also present on 80% of thymocytes, at a |
| 6137 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CD99 (EPR3097Y) |
MIC2 |
88,342 |
CD99, as detected with a variety of antibodies, is expressed by almost all Ewings sarcoma and primitive peripheral neuroectodermal tumors (ES/PNET) and demonstrates strong and diffuse membranous staining. Other tumors that may show CD99 expression include |
| 6138 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CDX-2 (EPR2764Y) |
CDX2, Caudal type homeobox 2 |
88,342 |
CDX-2 is a caudal-related homeobox transcription factor whose expression in the adult is normally present in the gastrointestinal (GI) epithelium. It is implicated in the development and maintenance of the intestinal mucosa. This protein is expressed immu |
| 6139 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CEA (EPCEAR7) |
Carcinoembryonic Antigen |
88,342 |
Carcinoembryonic antigen (CEA) is a 180-kDA cell surface glycoprotein overexpressed in 90% of gastrointestinal malignancies, including colon, gastric, rectal, and pancreatic tumors, 70% of lung cancers, and about 50% of breast cancers. |
| 6140 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Chromogranin (LK2H10) |
CHGA |
88,342 |
Chromogranin A is present in secretory granules of endocrine cells. Chromogranin A is a marker for neuroendocrine differentiation and antibodies to chromogranin A are a useful tool for the identification of neuroendocrine-derived tumors. Chromogranin A is |
| 6141 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Chymotrypsin (10-104.10) |
alpha-chymar ophth, chymotest, enzeon, quimar |
88,342 |
Chymotrypsin is a serine endopeptidase produced by the acinar cells of the pancreas. It is expressed within the secretory granules on the apical aspect of acinar cells. Chymotrypsin is one of the commonly used markers for identifying cells with pancreatic |
| 6142 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CK 19 (A53-B/A2) |
Cytokeratin 19 |
88,342 |
Anti-cytokeratin 19 reacts with epithelia and epithelial malignancies including carcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Anti-cytokeratin 19 is very useful in differentiation of hepatocellular carcinoma from intrahepa |
| 6143 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CK 20 (Ks20.8) |
Cytokeratin 20 |
88,342 |
CK 20 belongs to the intermediate filament proteins, which create a cytoskeleton in almost all cells. In contrast to other intermediate filaments, cytokeratins (CKs) are made up of a highly complex multigene family of 40 to 68 kDa polypeptides. Twenty di |
| 6144 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CK 5/6 (D5/16B4) |
Cytokeratine 5/6 |
88,342 |
Cytokeratin 5/6 (CK 5/6) stain distinguishes epithelioid mesothelioma (CK5/6+ in 83%) from lung adenocarcinoma (CK5/6- in 85%), including in pleural effusions (CK5/6+ in 90% mesothelioma, 0% adenocarcinoma). Can be also used to distinguish breast usual du |
| 6145 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CK 7 (OV-TL 12/30) |
Cytokeratin 7 |
88,342 |
Cytokeratin 7 belongs to the intermediate filaments, which create a cytoskeleton in almost all eukaryotic cells. In contrast to other intermediate filaments, cytokeratins (CKs) are made up of a highly complex multigene family of polypeptides with molecula |
| 6146 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CK OSCAR (OSCAR) |
Pancytokeratin OSCAR |
88,342 |
Cytokeratin (OSCAR) is a wide-spectrum cytokeratin. It stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells, making it a useful marker for identifying several types of carc |
| 6147 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CK8/18 (B22.1/B23.1) |
Cytokeratin 8 &18 |
88,342 |
Cytokeratins 8 & 18 (CK 8 & 18) can be found in most simple epithelia, e.g. thyroid, female breast, gastrointestinal tract, and respiratory tract.1 Adenocarcinomas and most non-keratinizing squamous carcinomas will stain with anti-CK 8 & 18, but keratiniz |
| 6148 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Claudin-4 (3E2C1) |
Clostridium perfringens enterotoxin receptor |
88,342 |
Claudin-4 (Clostridium perfringens enterotoxin receptor) is a tight junction protein encoded by the gene CLDN4. Claudin-4 has been shown to distinguish adenocarcinoma from malignant mesothelioma with 99% specificity in malignant effusions. Claudin-4 overe |
| 6149 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CLDN18 (43-14A) |
Claudin 18 |
88,360 |
Claudin 18.2 (CLDN18.2) is a member of the Claudin family of tight junction proteins and is normally expressed in non-neoplastic gastric epithelium. Tight junction proteins form a complex molecular network that plays a critical role in maintaining epithel |
| 6150 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CL-NOTCH1 (D3B8) |
Cleaved NOTCH1, Notch1 intracellular domain (NOTCH1-ICD) |
88,342 |
NOTCH1 is a member of the NOTCH family of transmembrane proteins. Upon ligand binding, the intracellular domain is released by cleavage between the Gly1753 and Val1754 residues. Upon cleavage, the free cytoplasmic domain mediates downstream signaling in |
| 6151 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Clusterin (41d) |
Apolipoprotein J, glycoprotein III, SGP-2 |
88,342 |
Clusterin is also known as apolipoprotein J, complement lysis inhibitor, gp80, glycoprotein III, SGP-2, SP 40-40, TRPM2 and T64. It is a ubiquitous multifunctional protein of 80kD comprised of two disulfide-linked subunits, alpha and beta, and is capable |
| 6152 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CMV (DDG9,CCH2) |
Cytomegalovirus |
88,342 |
Reacts with CMV immediate early antigen and early antigen. The antibody shows no cross-reaction with other herpesviruses or with adenovirus. Cytomegalovirus (CMV) is a common virus that infects people of all ages. In the United States, nearly one in three |
| 6153 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
c-MYC (Y69) |
MRTL |
88,342 |
c-MYC is a proto-oncogene that encodes the c-Myc protein, a transcription factor involved in cell proliferation. Abnormalities of c-MYC are found in many cancers and in many cases c-Myc is overexpressed as a result of translocations. Nearly 100% of Burkit |
| 6154 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CXCL-13 (53610) |
BLC, BCA-1 |
88,342 |
CXCL13 is a useful marker in the detection of angioimmunoblastic T cell lymphomas, and helps distinguish this entity from other T cell lymphomas. |
| 6155 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CyclinD1 (SP4-R) |
PRAD-1, BCL1 |
88,342 |
Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including ma |
| 6156 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
CYP11B2 (41-17B) |
Cytochrome P450 Family 11 Subfamily B Member 2, CYP11B, ALDOS, P-450C18, P450aldo, CYP11BL |
88,342 |
CYP11B2 encodes aldosterone synthase, a mitochondrial cytochrome P450 enzyme that catalyzes the final steps of aldosterone biosynthesis in the adrenal zona glomerulosa. It is responsible for the conversion of deoxycorticosterone to aldosterone and is a hi |
| 6157 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
D2-40 (D2-40) |
Lymphatic Endothelial Marker, PODOPLANIN, T1A-2 |
88,342 |
The monoclonal antibody D2-40 recognizes podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelium and lymphangiomas. This antibody stains the endothelium of lymph vessels but does not react with the endothelium of capillaries, a |
| 6158 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Desmin (D33) |
DES |
88,342 |
Desmin labels smooth and striated muscle cells as well as mesothelial cells and is a useful aid for the classification of rhabdomyosarcoma, leiomyoma, and mesothelioma. Desmin belongs to the class III of intermediate filaments, constituting part of the c |
| 6159 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
DOG-1 (K9) |
ANO1 |
88,342 |
DOG-1, a 986 amino acid protein of unknown function, is expressed predominantly on the plasma membrane of gastrointestinal stromal tumors (GISTs) and is rarely expressed in other soft tissue tumors, which, due to appearance, can be confused with GISTs. Re |
| 6160 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
DUX-4 (P4H2) |
Double homeobox 4 |
88,342 |
Round cell sarcoma with CIC-DUX4 gene fusion is known as CIC-DUX4 sarcoma. CIC-DUX4 sarcoma is exceptionally rare and represents a genetically defined subtype of undifferentiated round cell sarcoma that morphologically resembles the Ewing sarcoma family o |
| 6161 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
EBNA-2 (PE2) |
EBV nuclear antigen 2 |
88,342 |
The Epstein-Barr Virus (EBV), also called Human herpesvirus 4 (HHV-4), is a virus of the herpes family and is one of the most common viruses in humans. EBNA2 (EBV nuclear antigen 2) is one of the few genes of Epstein-Barr virus which are necessary for imm |
| 6162 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
EBV-LMP1 (CS1,2,3,4) |
Epstein–Barr virus Latent Membrane Protein1 |
88,342 |
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known viruses in the herpes family, and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis. It is also associated w |
| 6163 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
E-Cadherin (36) |
CDH1 |
88,342 |
E-cadherin is a calcium-regulated adhesion molecule expressed in most normal epithelial tissues. It is associated with gland formation, stratification, and epithelial polarization. Selective loss of E-cadherin can cause dedifferentiation and invasiveness |
| 6164 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
EMA (E29) |
Epithelial membrane antigen, MUC1 |
88,342 |
EMA antibody labels epithelial cells in a wide variety of tissues and is a useful tool for the identification of neoplastic epithelia. Epithelial membrane antigen (EMA) belongs to a heterogenous population of human milk fat globule (HMFG), proteins. HMFG |
| 6165 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Enolase (22C9) |
NSE, Enolase |
88,342 |
Enolases (2-phospho-D-glycerate hydrolase) are glycolytic homo- or heterodimeric isoenzymes, which catalyse the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. Three subunits, α (46 kDa), β (44 kDa) and γ (46 kDa), constitute the building b |
| 6166 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
EP4-Ber (EA) (Ber-EP4) |
Epithelial Antigen |
88,342 |
The antibody labels most epithelial cells and is a useful aid in the classification of adenocarcinoma. The antibody may also aid in the classification of esophageal carcinoma and classification of basal and squamous cell carcinomas of the skin. Epithelia |
| 6167 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ERG (EPR3864) |
Erythroblast transformation specific related gene |
88,342 |
Defects in ERG are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of mor |
| 6168 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Estrogen Receptor (SP1) |
ER |
88,360 |
Determination of ER status for all primary breast carcinomas was recommended by the National Institutes of Health (NIH) in 1979, to better determine appropriate therapy. In 1985, both the NIH and the American Cancer Society independently published reports |
| 6169 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
FACTOR XIII A (AC-1A1) |
Activated fibrin stabilizing factor |
88,342 |
Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-factor XIIIa has been found to be useful |
| 6170 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Fascin (IM20) |
p55 |
88,342 |
Human fascin is a highly conserved 55 kD actin-bundling protein which shares extensive sequence homology with sea urchin fascin and the Drosophila singed gene (sn) protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to micr |
| 6171 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Fast-Slow Myosin (MY-32, NOQ7.5.4D) |
Fast Myosin: Myosin-1, Myosin heavy chain 1 Slow Myosin: Myosin-7, Myosin heavy chain 7 |
88,344 |
Actomyosin filaments represent the principal structural contractile components of muscle cell sarcomeres. Myosin is a molecular motor that converts chemical energy into movement. This is established by sliding of actin and myosin filaments over each other |
| 6172 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
FH (J-13) |
Fumarate Hydratase |
88,342 |
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is an autosomal disorder caused by germline mutation in the fumarate hydratase (FH) gene on chromosome 1q43. HLRCC associated RCC is often aggressive with metastatic disease in 50% of pat |
| 6173 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
FOLR1 (FOLR1-2.1) |
Folate Receptor Alpha, Ovarian Tumor-Associated Antigen MOv18 |
88,360 |
Epithelial ovarian cancer, which constitutes over 90% of ovarian cancer cases, is a leading cause of gynecologic mortality worldwide and has a limited number of effective therapeutic agents. Folate receptor alpha (FRα), encoded by the FOLR1 gene, has emer |
| 6174 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
FosB (5G4) |
AP-1 transcription factor subunit |
88,342 |
FOSB is a member of the FOS gene family (FOS, FOSB, FOSL1 and FOSL2). These genes encode leucine zipper proteins that dimerize with proteins of the HUN family, forming the transcription factor complex AP-1.1,2 In this role, FOSB protein has been implica |
| 6175 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Gastrin (P) |
GAST |
88,342 |
Gastrin is a peptide hormone secreted by G cells that stimulates secretion of HCl by parietal cells in the pyloric antrum of the stomach, duodenum, and pancreas. It also increases gastric motility. Gastrinomas are pancreatic islet cell tumors that hyper |
| 6176 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GATA3 (L50-823) |
GATA Binding Protein 3 |
88,342 |
Studies have shown GATA-3 orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently |
| 6177 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GCET1 (RAM341) |
Centerin, Seprin A9, SERPINA11, SERPINA11b, SERPINA9, Serine proteinase inhibitor A11, Germinal center B cell expressed transcript 1 protein |
88,342 |
Germinal center (GC) B cell-expressed transcript 1 (GCET1) is a molecule that belongs to the family of serine-protease inhibitors or serpins. Expression of GCET-1 has been found in GC B cells and GC B cell-derived malignancies but not in resting or activa |
| 6178 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GFAP (P) |
Glial fibrillary acidic protein |
88,342 |
Glial fibrillary acidic protein (GFAP) is the principal intermediate filament of mature astrocytes, and the antibody is a useful tool for the identification of astrocytes in the central nervous system (CNS) under normal and pathological conditions. GFAP i |
| 6179 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GH (P) |
hGH, growth hormone, somatotropin |
88,342 |
Human growth hormone (hGH) is a polypeptide produced and secreted by somatotrophs of the anterior pituitary gland (adenohypophysis). Somatotrophs account for approximately 50% of all anterior pituitary cells. Positive immunohistochemical staining for hGH |
| 6180 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GLUT1 (EP141) |
Glucose transporter 1, SLC2A1 |
88,342 |
Glucose transporter 1 (GLUT1), the most abundant isoform among the human glucose transporter family (GLUT 1-14), controls cellular glucose uptake and plays an essential role in energy metabolism. Immunohistochemistry (IHC) studies have shown that GLUT1 is |
| 6181 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Glutamine Synth. (GS-6) |
GS |
88,342 |
Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits. Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an |
| 6182 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Glycophorin A (GA-R2) |
GYPA, CD235a |
88,342 |
Glycophorin A is a sialoglycoprotein expressed in mature erythrocytes and nucleated erythroid precursors. Glycophorin A is a membrane protein carrying antigenic determinants for blood group specificities. The high sialic acid content of glycophorin A co |
| 6183 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Glypican-3 (1G12) |
GPC3 |
88,342 |
Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Recently, GPC3 was identified to be a useful tumor marker for the diagnosis of HCC, hepatoblastoma, melanoma, testicular germ cell t |
| 6184 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GPNMB (E4D7P) |
Glycoprotein Nmb, HGFIN |
88,342 |
Renal cell carcinoma (RCC) classification has historically been based on morphology, with clear cell RCC, papillary RCC, and chromophobe RCC. However, with the advances in molecular phenotyping classification of these tumors solely based on morphology has |
| 6185 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
GranzymeB (GrB-7) |
GZMB |
88,342 |
The granzyme B mouse monoclonal antibody reacts with the 33 kD human serine protease granzyme B. It does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasm |
| 6186 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
H.Pylori (SP48) |
Helicobacter pylori |
88,342 |
Helicobacter pylori (H. pylori) can exist in a number of locations: in the mucus, attached to epithelial cells, or inside of vacuoles in epithelial cells, where it produces adhesions that bind to membrane-associated lipids and carbohydrates in or on epith |
| 6187 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
H3 K27me3 (C36B11) |
Tri-Methyl-Histone H3 Lys27 Wild Type |
88,342 |
In most cells, histone 3 (H3) is trimethylated at lysine 27 (H3K27) as a consequence of the activity of the polycomb repressive complex (PRC2). It is designated “wild type”. In 70-90% of cases of malignant peripheral nerve sheet tumor (MPNST), constitue |
| 6188 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
H3 K27Mutant (EPR18040) |
H3K27M Mutant |
88,342 |
Recurrent K27M mutations in histone 3 (H3) have been detected in midline high grade astrocytomas and have been associated with rapid fatal outcomes. Mutated cases tend to be diagnosed in children, in pontine and midline locations. |
| 6189 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
H3 K36M (RM193) |
Histone H3 (K36M Mutant Specific) |
88,342 |
H3F3B is a member of the histone H3 family and is located on chromosome 17. Histone H3 K36M is expressed in the nuclei of the mononuclear cell population of H3F3B altered chondroblastoma. Somatic missense mutations in histone H3 genes are found in several |
| 6190 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
H3G34W (RM263) |
Histone H3.3 G34W mutant |
88,342 |
Nuclear chromatin is composed of nucleosomes, each containing a histone multimer wrapped by DNA. Mutations of histones, which can lead to alteration of gene expression and chromosomal stability, have been described in several types of neoplasms. The his |
| 6191 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HbcAG (P) |
Hepatitis B Core Antigen |
88,342 |
Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical |
| 6192 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HBME-1 (HBME-1) |
Mesothelial Cell, Hector Battifora mesothelial-1 |
88,342 |
Hector Battifora mesothelial-1 (HBME-1) is a membrane antigen that exists in the microvilli of mesothelial cells and other epithelial cells. Anti-HBME-1 labels thyroid papillary carcinoma and follicular carcinoma but not normal thyroid making it a valuab |
| 6193 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HbsAG (A10F1) |
Hepatitis B surface antigen |
88,342 |
Hepatitis B surface antigen (HBsAg) contains the large, middle, and small proteins of the Hepatitis B virus (HBV). HBsAg is on the surface of HBV that is present in the bodily fluids and hepatocytes of infected individuals. It plays a key role in HBV’s in |
| 6194 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
H-Caldesmon (h-CD) |
CALD1 |
88,342 |
This antibody labels smooth muscle cells and is a useful aid in the classification of tumors with smooth muscle cell differentiation. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction. Two closely relate |
| 6195 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HCG (P) |
Human chorionic gonadotropin |
88,342 |
Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of alpha and beta subunits, synthesized in syncytiotrophoblastic cells of placenta and in certain trophoblastic tumors such as choriocarcinoma. The alpha subunit of hCG is identical to |
| 6196 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HEG1 (SKM9-2) |
HEART DEVELOPMENT PROTEIN WITH EGF-LIKE DOMAINS 1 |
88,342 |
HEG homolog 1 (HEG1) is a novel calcium binding receptor protein that plays a role in endothelial cell interactions in the development of the vascular system and angiogenesis. HEG1 has been shown to be a useful marker in the diagnosis of mesothelioma, an |
| 6197 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Hemoglobin-A (SP212) |
HGB A |
88,342 |
Hemoglobin belongs to the globin family of proteins and is involved in oxygen transport from the lung to the various peripheral tissues. Hemoglobin A is comprised of two alpha chains and two beta chains. Immunohistochemical localization of hemoglobin A s |
| 6198 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Hepatocyte (OCH1E5) |
HEP-PAR1 |
88,342 |
Monoclonal antibody Hep Par 1 is an antigen that seems to be localized to the mitochondrial fraction of liver homogenates in both fetal and adult liver. It is conserved in most adult hepatocellular carcinomas including fibrolamellar variants. Hepatoblasto |
| 6199 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HER2 (4B5) |
CERB2 |
88,360 |
Breast cancer is the most common carcinoma occurring in women, and the second leading cause of cancer related death. In North America, a woman’s chance of contracting breast cancer is one in eight. Early detection and appropriate treatment therapies can s |
| 6200 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Herpes (HSVI&II) (10A3/ BSB-116) |
Herpes Simplex Virus I and II; HSV I & II |
88,342 |
Herpes simplex viruses -- more commonly known as herpes -- are categorized into two types: herpes type 1 (HSV-1 or oral herpes) and herpes type 2 (HSV-2 or genital herpes). Most commonly, herpes type 1 causes sores around the mouth and lips (sometimes cal |
| 6201 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HHV8 (13B10) |
Human Herpesvirus 8 |
88,342 |
Human herpes virus type 8 (HHV-8) is the likely etiological agent of Kaposi’s sarcoma (KS). HHV-8 DNA sequences have been found in KS lesions and primary effusion lymphoma. Other conditions in which HHV-8 has been associated include multicentric Castleman |
| 6202 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HMB-45 (HMB-45) |
Anti-Melanoma |
88,342 |
Metastatic amelanotic melanoma is often confused with a variety of poorly differentiated carcinomas, sarcomas, and large cell lymphomas. Primary spindle cell melanomas may also mimic spindle cell carcinomas and various types of mesenchymal neoplasms. HMB4 |
| 6203 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HMGA2 (EP398) |
High Mobility Group AT-Hook, HMGIC |
88,342 |
High mobility group A2 protein (HMGA2) is a non-histone, chromatin-associated molecule involved in maintenance and functional regulation of DNA, including the processes of replication, recombination, transcription, and DNA repair. HMGA2 is important durin |
| 6204 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
HPV (K1H8) |
human papillomavirus |
88,342 |
Anti-human papillomavirus, clone K1H8 (anti-HPV) reacts with a non-conformational internal linear epitope of a major capsid protein of HPV-1, which is broadly expressed among the different HPV subtypes. Anti-HPV was found to be immunoreactive with paraffi |
| 6205 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
ICOS (D1K2T) |
CD278, Inducible co-stimulator |
88,342 |
ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T cell activity and immune responses (1-2). The ICOS protein contains an extracellular IgV like domain, a transmembrane domain, and an intracellular domain with a YMFM mot |
| 6206 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IDH-1 (H09) |
Isocitrate dehydrogenase 1 |
88,342 |
Isocitrate dehydrogenase 1 (IDH1) is an important enzyme in the tricarboxylic acid cycle. It catalyzes the cytosolic oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2 while converting NAD+ to NADH. High frequency of IDH1 mutat |
| 6207 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IDH2 (R172K) (14H7F11) |
Isocitrate Dehydrogenase (NADP(+)) 2 with R172K mutation |
88,342 |
Mutations in isocitrate dehydrogenase 2 (IDH2) are identified in a subset of hematolymphoid neoplasms including acute myeloid leukemia and T-cell lymphomas of T follicular helper type with the R172K mutation being one of the most frequently identified mut |
| 6208 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IgA (N1CLA) |
Immunoglobulin A |
88,342 |
IgA is one of the most prevalent of the five classes of antibodies produced by the body. It is found in all secretions of the body and is the major antibody in the tears, saliva, and mucous membranes lining the intestines and bronchi. IgA combines with a |
| 6209 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IgD (DRN1C) |
Immunoglobulin D |
88,342 |
Immunoglobulins function as the surface receptors in B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system. IgD is normally expressed on mantle zone B-cells. The identification of IgD on B-cell subsets |
| 6210 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IgG (RWP49) |
Immunoglobulin G |
88,342 |
Immunoglobulins are heterodimeric proteins composed of two heavy chains and two light chains. Immunoglobulin G (IgG) is the most common type of antibody in serum and is normally produced by plasma cells to aid in the control of various types of pathogens. |
| 6211 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IgG4 (HP6025) |
Immunoglobulin G4 |
88,342 |
Early studies suggest that IgG4 as a serum and IHC tissue marker may be a sensitive diagnostic aide in AIP and a specific marker to differentiate this rare variant of chronic pancreatitis from usual type chronic pancreatitis due to alcoholism and gallston |
| 6212 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IgM (P) |
Immunoglobulin M |
88,342 |
IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunogl |
| 6213 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Inhibin (alpha) (R1) |
Inhibin A, Inhibin alpha |
88,342 |
Inhibin and activin are part of the transforming growth factor beta (TGF-ß) family of cytokines and are best known for their role in regulating follicle stimulating hormone (FSH) secretion, where inhibin inhibits and activin activates secretion. These pro |
| 6214 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
INI-1 (25/BAF47) |
SNF5, SMARCB1, BAF47 |
88,342 |
The SMARCB1/INI-1 gene is a member of the ATP-dependent SWI/SNF chromatin-remodeling complex and has been considered as a tumor suppressor gene. All normal cells show nuclear expression of INI-1 protein. Biallelic inactivation of the INI-1 gene & absence |
| 6215 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
INSM1 (SP493) |
Insulinoma-associated protein 1; zinc finger protein IA-1 |
88,342 |
INSM1 (insulinoma-associated protein 1), also known as zinc-finger protein IA-1, is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. |
| 6216 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IRF8 (EPR20441) |
Interferon Regulatory Factor 8, ICSBP |
88,342 |
Interferon Regulatory Factor 8 (IRF8) is a lineage-specific transcription factor of the interferon (IFN) regulatory factor (IRF) family that is critical for the production of monocytic and dendritic cell progenitors. Its expression highly correlates with |
| 6217 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
IRTA1 (EPR21961) |
FCRL4 |
88,342 |
Immune receptor translocation-associated protein 1 (IRTA1), also known as Fc receptor–like 4 (FCRL4), is a member of a family of immunoglobulin-like proteins that mediate B-cell immune responses. In normal lymphoid tissues, IRTA1 is expressed in benign m |
| 6218 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Kappa (P) |
KAPPA LIGHT CHAINS |
88,342 |
The human immunoglobulins basically consist of two identical heavy chains (Mr about 50 000) and two identical light chains (Mr about 20 000). The four chains are covalently linked together by disulphide bonds. The light chains are either kappa or lambda. |
| 6219 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
KER 903 (34BE12) |
Cytokeratin 1/5/10/14, HMWCK |
88,342 |
KER903 (34βE12) is specific for "high molecular weight" cytokeratins 1, 5, 10 and 14, corresponding to molecular weights 68, 58, 56.5 and 50 kDa, respectively, which are characteristically found in "complex" epithelium. The antibody reacts with all squamo |
| 6220 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Ki 67 (30-9) |
Marker Of Proliferation Ki-67 |
88,360 |
The Ki-67 antigen is a proliferation marker and is expressed by cells within the cell cycle but not in resting cells. Studies have shown this antigen to be expressed throughout S phase, G2 phase and M phase of the cell cycle but absent in G 0. It is a n |
| 6221 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Ki67/MelanA |
Ki67/Melan A Double Stain or Dual Stain |
88,344 |
The Ki-67 antigen is a proliferation marker and is expressed by cells within the cell cycle but not in resting cells. Studies have shown this antigen to be expressed throughout S phase, G2 phase and M phase of the cell cycle but absent in G0. It is a nucl |
| 6222 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Lambda (P) |
LAMBDA LIGHT CHAINS |
88,342 |
The human immunoglobulins basically consist of two identical heavy chains (Mr about 50 000) and two identical light chains (Mr about 20 000). The four chains are covalently linked together by disulphide bonds. The light chains are either kappa or lambda. |
| 6223 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Langerin (P) |
CD207 |
88,342 |
Langerin is a highly selective marker for benign Langerhans cells and for the lesional cells of Langerhans cell histocytosis. Langerhans cells are normally present in many tissues, including lymph node and skin (tissues that could be used as positive con |
| 6224 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
LEF1 (EP310) |
Lymphoid Enhancer Binding Factor 1, TCF1ALPHA |
88,342 |
Lymphoid enhancer-binding factor-1 (LEF1), also known as T cell factor protein 1 alpha (TCF-1α), is a member of the LEF/TCF family of transcription factors. LEF1 plays a key role in the WNT signaling pathway via direct interaction with β-catenin and subse |
| 6225 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
LMO2 (SP51) |
LIM domain only 2; LIM-only transcription factor-2; rhombotin-like 1 |
88,342 |
LMO2 is expressed in normal germinal center B-cells and in a subset of lymphomas derived from those cells in addition to bone marrow hematopoietic precursors and endothelial cells. LMO2 protein expression also plays an important role in the diagnosis of d |
| 6226 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MAL (E-1) |
Myelin and Lymphocyte Protein |
88,342 |
MAL (myelin and lymphocyte protein), also known as T lymphocyte maturation-associated protein, is a nonglycosylated hydrophobic integral membrane protein belonging to the MAL family of proteolipids. MAL is highly enriched in nervous system myelin and in r |
| 6227 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MAMMAGLOBIN (31A5) |
Mammaglobin-1, Secretoglobin family 2A member 2, MGB1, UGB2. |
88,342 |
Breast cancer is known for its morphologic diversity and diagnosis of metastatic breast carcinoma can be challenging. Mammaglobin is a breast-associated glycoprotein that belongs to the secretoglobin superfamily. It is expressed by normal mammary tissue a |
| 6228 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
McPyV (CM2B4) |
Merkel Cell Polyomavirus |
88,342 |
Merkel cell polyomavirus (MCPyV) infections are typically benign. However, in rare instances, these infections can lead to a neoplastic transformation of Merkel cell carcinoma through the expression of MCPyV large T-antigen (nuclear expression). Merkel c |
| 6229 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MDM2 (IF2) |
mouse (or murine) double minute 2 |
88,342 |
Well-differentiated liposarcoma / atypical lipomatous tumor (WDLS/ALT) are among the most common malignant soft tissue tumors presenting in older adults. These tumors typically arise in the deep soft tissue of the proximal lower extremities as slow growin |
| 6230 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MEF2B (EPR22192-78) |
Myocyte Enhancer Factor 2B, RSRFR2, Serum Response Factor-Like Protein 2, MADS Box Transcription Enhancer Factor 2 |
88,342 |
Myocyte Enhancer Factor 2B (MEF2B) is a product of the MADS/MEF2 family of DNA binding proteins initially identified as important regulators of myocyte differentiation. MEF2B is highly expressed in germinal center B-cells and appears critical in germinal |
| 6231 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Melan A (A103) |
MART-1 |
88,342 |
Melan-A, product of MART-1gene, is a differentiation antigen which is expressed in 100% of melanocytes, most melanomas, and 50-60 percent of melanoma cell lines. It was identified as one of the melanoma antigens recognized by autologous cytotoxic T cells, |
| 6232 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MET (SP44) |
MET Proto-Oncogene, Receptor Tyrosine Kinase, C-Met |
88,342 |
Assessment of MET alterations is increasingly important for lung cancer therapy decision making. MET immunohistochemistry against the carboxyl region of the human MET protein is used to identify a subset of non-squamous non-small cell lung carcinoma pati |
| 6233 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MiTF (C5+d5) |
Microphthalmia Transcription Factor |
88,342 |
MiTFis a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of Mi exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanom |
| 6234 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MLH-1 (M1) |
MutL homolog 1 (E. coli) |
88,342 |
The anti-MLH1 antibody, clone M1, recognizes MLH1, one of several mismatch repair (MMR) proteins that are mutated in families with hereditary non-polyposis colorectal cancer (HNPCC). Carriers of these mutations have a high risk of developing colorectal, u |
| 6235 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MOC-31 (MOC-31) |
Anti-Epithelial Specific Antigen |
88,342 |
MOC-31 is a monoclonal antibody which recognizes an approximately 41-kilodalton, membrane-based glycoprotein (epithelial glycoprotein2, EGP-2) of unknown function. Immunohistochemical studies have shown that MOC-31 is expressed in a wide range of carcinom |
| 6236 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MSH-2 (G219-1129) |
MutS homolog 2 (E. coli) |
88,342 |
MSH2 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as hereditary nonpolyposis colon cancer (HNPCC). The anti-MS |
| 6237 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MSH-6 (SP93) |
mutS homolog6 |
88,342 |
Colorectal cancer (CRC) is the third most common cancer and the fourth most prevalent cause of death in the world. The majority of CRCs show chromosomal instability, however approximately 15% of cancers develop through an alternative pathway characterize |
| 6238 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MUC-4 (8G-7) |
Mucin 4 |
88,342 |
MUC4 (mucin 4) is a large membrane-anchored glycoprotein of the mucin family that is expressed by epithelial cells in various normal tissues including lung, bronchus, stomach, colon, and cervix. MUC4 is generally not detected in normal pancreas but is ex |
| 6239 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MUM-1 (MUM1p) |
IRF4 |
88,342 |
MUM1 protein (multiple myeloma oncogene-1) is a 50 kDa protein encoded by the MUM1 gene that was originally identified because of its involvement in the rare t(6;14) (p25;q32) translocation observed in multiple myeloma (MM), causing juxtaposition of the M |
| 6240 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Muramidase (P) |
Lysozyme |
88,342 |
Muramidase (Lysozyme) has been shown to have cytoplasmic expression in hematopoietic cells and non-hematopoietic cells, like renal proximal convoluted tubules. Lysozyme may be used as a non-specific marker of tissue macrophages (such as alveolar macrophag |
| 6241 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Myeloperoxidase (59A5) |
MPO |
88,342 |
Anti-myeloperoxidase detects granulocytes and monocytes in blood and precursors of granulocytes in the bone marrow. This antibody can detect myeloid cell populations of the bone marrow as well as in other sites. This antibody is indicated as an aid in the |
| 6242 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
MyoD1 (EP212) |
Myogenic Differentiation 1Ce |
88,342 |
The MyoD1 protein is a 45 kD nuclear phosphoprotein which induces myogenesis through transcriptional activation of muscle-specific genes. Nuclear expression of MyoD1 is restricted to skeletal muscle tissue and has been demonstrated to be a sensitive marke |
| 6243 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Myogenin (F5D) |
BHLHc3, Myogenic Factor 4 |
88,342 |
Anti-Myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilm’s tumor. |
| 6244 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Napsin A (MRQ-60) |
Napsin A aspartic peptid |
88,342 |
Napsin A is an aspartic proteinase and plays a role in pneumocyte surfactant processing. It is expressed in normal adult lung tissue, specifically labeling type II pneumocytes and epithelial cells in kidney tissues. Recent studies have demonstrated that N |
| 6245 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Neu-N (A60) |
Neuronal nuclei |
88,342 |
NeuN antibody (Neuronal Nuclei; clone A60) specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to n |
| 6246 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Neurofilament (2F11) |
NF |
88,342 |
Neurofilaments (NFs) belong to the family of intermediate filaments (IFs) and are structural elements of the neuronal cytoskeleton in an interconnection with actin microfilaments, microtubules and other IFs. NFs are composed of three different subunits th |
| 6247 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
NK1/C3 (NK1/C3) |
CD63 |
88,342 |
CD63 is a 53kDa lysosomal membrane protein in the family of tetraspan moieties, and characterized as an activation dependent platelet surface antigen. Anti-CD63 reactivity is seen in the cytoplasm of many cell types including lymphoid, myeloid, endothelia |
| 6248 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
NKX2.2 (EP336) |
NK2 Homeobox 2, NKX2B |
88,342 |
NKX2.2 is an NK2 family homeodomain transcription factor, a down-stream target of EWSR1::FLI1 gene fusion associated with Ewing sarcomas. The immunohistochemistry antibody is used as part of a panel with other immunohistochemical stains to distinguish Ew |
| 6249 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
NKX3.1 (EP356) |
NK3 Homeobox 1, NKX3, BAPX2, NKX3A, NKX3.1, Bax, bagpipe, NKX3-1 |
88,342 |
NKX-3.1 is a protein found in humans and is encoded by the NKX3-1 gene located on chromosome 8. The homeodomain containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-reg |
| 6250 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
NPM-1 (P) |
mutated nucleophosmin 1, mutated B23 |
88,342 |
The presence of NPM1 mutations are frequently identified within acute myeloid leukemia. The presence of an NPM1 in the appropriate setting can be used to define a category of AML (AML with mutated NPM1) within the 2016 WHO monograph and tend to be seen in |
| 6251 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
NRAS (RBT-NRAS) |
NRAS Proto-Oncogene, GTPase with Q61R mutation |
88,342 |
NRAS oncogene is a member of the Ras gene family which is involved in normal control of cell growth. Mutations in NRAS have been seen in melanomas, acute myeloid leukemia and thyroid cancers. Specifically, the NRAS (Q61R) mutation has been associated wi |
| 6252 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
NUT (C52B1) |
NUTM1, NUT midline carcinoma family member 1; Nuclear protein in testis |
88,342 |
Nuclear protein in testis (NUT), which is normally expressed only in germ cells of the testis and ovary, regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. NUT midline carcinoma (NMC) is a rare, clinically aggressive carc |
| 6253 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
OCT 2 (MRQ2) |
Octamer Transcription Factor 2 |
88,342 |
Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and, despite the scarce evidence for Oct-2 expression in T ce |
| 6254 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
OCT 3/4 (C-10) |
POU5F1 (POU domain, class 5, transcription factor 1 |
88,342 |
The recently described marker, OCT3/4, a nuclear transcription factor and marker of pluripotency, has been found in both normal immature and malignant germ cells, known as carcinoma in situ/intratubular germ cell neoplasia unclassified (CIS/ITGCNU). ITGCN |
| 6255 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Olig2 (211F1.1) |
Oligodendrocyte transcription factor / Oligodendrocyte lineage transcription factor 2 |
88,342 |
Olig2, a basic helix-loop-helix (bHLH) transcription factor, is involved in oligodendroglial specification. Olig2 expression was restricted to glial tumors and nontumoral oligodendrocytes. It was higher in oligodendrogliomas when compared to astrocytomas. |
| 6256 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
P120 catenin (98) |
CTNND1, Catenin Delta 1, P120 |
88,342 |
p120 catenin is a tyrosine kinase that binds to E-cadherin within the cell membrane. Absence of E-cadherin at the cell membrane transports p120 catenin into the cell cytoplasm. Cytoplasmic expression of p120 catenin is useful in the distinction between l |
| 6257 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
P16 (E6H4) |
CDKN2A, Cycln Dependent Kinase Inhibitor 2A, CDK4, Inhibitor P16-INK4 |
88,342 |
As a cyclin-dependent kinase inhibitor, p16INK4a (p16) plays a key role in cell cycle regulation and cellular differentiation. The p16 protein controls the retinoblastoma protein (pRB)-mediated G1-S phase transition and triggers cell cycle arrest in the c |
| 6258 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
P40 (BC28) |
ΔNp63 |
88,342 |
The mouse monoclonal antibody p40 [clone BC28] recognizes an epitope unique to the p40 protein and may have applications in cases where p63 has traditionally been used. To date, p63 [clone 4A4] has been a frequently used marker for lung squamous cell carc |
| 6259 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
P53 (DO-7) |
Tumor protein 53, TP53 |
88,360 |
p53 is a nuclear phosphoprotein with a molecular mass of 53 kDa. Wild-type p53 protein is present in a wide variety of normal cells, but the protein has a very short half-life and thus is present in only minute amounts, generally below the detection level |
| 6260 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
P57 (KP10) |
CDKN1C |
88,342 |
P57 protein is encoded by the CDKN1C gene, which is strongly paternally imprinted and expressed exclusively from the maternal allele. Complete hydatidiform mole (CHM) contains only paternal genes & has been proven to display reduced or absent P57 protein |
| 6261 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
P63 (4A4) |
KET, p53, p40, p73L |
88,342 |
The human p63 protein is a member of the p53 family of transcription factors, and has six major isoforms. The p63 protein is highly expressed in the basal or progenitor cells of a variety of epithelial tissues, including those of the prostate, breast, eso |
| 6262 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
p63-ERG |
p63: KET, p51, p40, and p73L; ERG: ETS Transcription Factor ERG |
88,344 |
The TMPRSS2-ERG gene fusion has been found to be highly specific for prostate cancer and presented in approximately 50% of prostate cancer cases. TMRRSS2-ERG gene fusions result in a truncated ERG protein product which can be detected by immunohistochemis |
| 6263 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Pan-TRK (EPR17341) |
Tropomyosin receptor kinase proteins A, B, and C |
88,342 |
Tropomyosin, or tyrosine, receptor kinase (Trk) family members play a role within the nervous system by binding neurotrophins to affect both neuronal differentiation and survival. The neurotrophic receptor kinase 1 (NTRK1), NTRK2, and NTRK3 genes encode p |
| 6264 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Parvovirus (R92F6) |
Erythrovirus B19, B19V |
88,342 |
Parvovirus B19 manifestations of infection vary with the immunologic and hematologic status of the host. In the immunocompromised host persistent parvovirus B19 infection is manifested as pure red cell aplasia and chronic anemia. Likewise, the immature im |
| 6265 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PAX2 (EP235) |
Paired box gene 2 |
88,342 |
PAX2 is a transcription factor that, during embryonic development, codes for a protein that is involved in the formation of the eye, ear, central nervous system, kidney, and genital tract. After birth, the PAX2 protein is thought to protect against cell d |
| 6266 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PAX5 (SP34) |
B-cell specific activator protein (BSAP) |
88,342 |
PAX5, also known as B-cell specific activator protein (BSAP), is a member of the paired box (PAX) family of transcription factors. Within lymphocytes, PAX5 is expressed in B-cell precursors and mature B-cells, but is lost as B-cells mature into plasma c |
| 6267 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PAX8 (SP348) |
Paired Box 8 |
88,342 |
PAX8 is a member of the paired box (PAX) family of cell lineage restricted transcription factors that are expressed in specific primordial tissues in the embryonic stages and in differentiated adult tissues. These lineage restricted transcription factors |
| 6268 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PD1 (NAT105) |
Programmed Cell Death 1; CD279; Ly101 |
88,342 |
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) represents approximately 5% of all cases of Hodgkin lymphoma and is considered to be a distinct entity. The histologic findings often overlap with T-cell/histiocyte rich B-cell lymphoma (T/HRBCL), ma |
| 6269 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PD-L1 (22C3) |
Programmed Death – Ligand 1 |
88,360 |
Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T cell proliferation and cytokine production. PD-L1 expression in tumor cells can be used as a prognostic indicator that anti-PD-1 immunotherapy may prolong lif |
| 6270 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PERFORIN (MRQ-23) |
PRF1 |
88,342 |
Perforin plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejecti |
| 6271 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PHOX2B (EP312) |
Paired-like homeobox 2b |
88,342 |
PHOX2B is a transcription factor encoded by the PHOX2B gene, playing a crucial role in neuronal development by regulating maturation and differentiation. It is highly specific to the peripheral autonomic nervous system. PHOX2B is predominantly expressed i |
| 6272 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PIN3 (P504S+P63+34BE12) |
Prostatic intraepithelial neoplasia |
88,344 |
This two-color, three-antibody stain includes 34β12 and p63 with a brown chromogen and p504s in a red chromogen. In the prostate, 34βE12 and p63 stain normal basal cells, while p504s (AMACR) is generally negative or only very faintly positive in normal g |
| 6273 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Pit-1 (D-7) |
POU1F1, POU Class 1 Homeobox 1 |
88,342 |
Pit-1 determines the differentiation of growth hormone (somatotroph, lactotroph, and thyrotroph) cells within the pituitary gland. The nuclear expression of Pit-1 is retained in the pituitary tumor cells that are differentiated towards their respective pi |
| 6274 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PLAG1 (3B7) |
PLAG1 Zinc Finger, ZNF912, Pleomorphic Adenoma Gene |
88,342 |
PLAG1 gene plays an important role in the regulation of cell growth and differentiation. It belongs to the PLAG family of transcription factors and is expressed in a variety of tissues, including the salivary glands, pituitary gland, and adrenal gland. PL |
| 6275 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PLAP (8A9) |
Placental alkaline phosphatase |
88,342 |
Placental alkaline phosphatase (PLAP) is normally produced by primordial germ cells and placental syncytiotrophoblasts, and the detection of its expression has been useful in identifying germ cell tumors. Anti-PLAP antibody immunoreacts with germ cell tu |
| 6276 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PMS2 (A16-4) |
PMS1 Homolog 2 |
88,342 |
Colorectal cancer (CRC) is the third most common cancer and the fourth most prevalent cause of death in the world. The majority of CRCs show chromosomal instability, however approximately 15% of cancers develop through an alternative pathway characterize |
| 6277 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PRAME (EPR20330) |
PReferentially expressed Antigen in MElanoma |
88,360 |
PRAME (preferentially expressed antigen in melanoma) is an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a r |
| 6278 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Progesterone Receptor (1E2) |
PR |
88,360 |
Determination of ER status for all primary breast carcinomas was recommended by the National Institutes of Health (NIH) in 1979, to better determine appropriate therapy. In 1985, both the NIH and the American Cancer Society independently published reports |
| 6279 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PROLACTIN (EP193) |
Luteotropin |
88,342 |
Prolactin (PRL) is a single-chain polypeptide of 226 amino acids and plays a role in multiple processes including cell growth, reproduction, and immune function. Anti-Prolactin reacts with prolactin-producing cells and is a useful marker in classification |
| 6280 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PSA (EP109) |
Prostate Specific Antigen, Kallikrein-3 |
88,342 |
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium. Studies have shown that PSA is used to confirm prostatic acinar cell origin in primary and metastatic carcinomas and to rule out non-prostatic carcinoma mi |
| 6281 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PSAP (PASE/4LJ) |
Prostate-specific acid phosphatase |
88,342 |
Anti-PSAP reacts with prostatic acid phosphatase in the glandular epithelium of normal and hyperplastic prostate, carcinoma of the prostate, and metastatic cells of prostatic carcinoma. This marker may be helpful in pinpointing the site of origin in cases |
| 6282 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PSMA (3E6) |
Prostate specific membrane antigen, GCP2 |
88,342 |
Prostate specific membrane antigen (PSMA) is a 750 amino acid type II membrane glycoprotein with folate hydrolase and neuropeptidase activity. PSMA is expressed in normal and malignant prostatic epithelium and in a subset of non-prostatic tissues. In pros |
| 6283 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PTEN (138G6) |
Phosphatase And Tensin Homolog, |
88,342 |
Endometrial carcinoma is the most common malignancy of the female genital tract. It is a heterogeneous disease that has traditionally been divided into type 1 and type 2 cancers. Type 1 tumors are low grade endometrioid carcinomas and are generally associ |
| 6284 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PTH (MRQ-31) |
Parathyroid Hormone |
88,342 |
The parathyroid glands function within the endocrine system to promote blood calcium homeostasis through controlled release of parathyroid hormone (PTH). This process involves the synthesis and secretion of PTH by activated parathyroid chief cells during |
| 6285 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
PU.1 (9G7) |
SPI1, SPI-A, SFPI1 |
88,342 |
PU.1 is a transcriptional activator and ETS oncogene family member based on similarity to the v-ets oncogene from the avian retrovirus E26 which causes erythroid and myeloid leukemias in chickens. PU.1 is highly expressed in cells of myeloid and B-lymphoi |
| 6286 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Rb1 (G3-245) |
Retinoblastoma Protein, Rb |
88,342 |
Retinoblastoma gene/protein is a tumor suppressor gene at 13q14. Encodes a 110-114 kDa nuclear protein that plays a crucial role in cell cycle progression by regulating cell cycle arrest at G1-S. Somatic mutations can cause various tumors and aberrant/l |
| 6287 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
S100 (P) |
S100 Calcium Binding Protein |
88,342 |
S100 antibody labels cells expressing S100 and is a useful aid for the classification of neoplasms, such as malignant melanoma, Langerhans' histiocytosis, chondroblastoma, and schwannoma. Differential classification is aided by the results from a panel of |
| 6288 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SALL4 (6E3) |
DRRS, HSAL4, MGC133050, ZNF797, Dj1112f19.1 |
88,342 |
Sal-like protein 4 (SALL4) is a zinc finger-containing transcription factor that belongs to the Spalt/Sal transcription factor family. It has been known as a stem cell marker because of its role in the maintenance of self-renewal and pluripotency of embry |
| 6289 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SATB2 (EP281) |
Special AT-rich sequence binding protein 2 |
88,342 |
Special AT-rich sequence-binding protein 2 (SATB2) binds specifically to nuclear matrix attachment regions of DNA. It functions as a transcriptional regulator and is involved in chromatin remodeling. Recently, SATB2 has been identified as a sensitive and |
| 6290 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SDHA (2E3GC12FB2AE2) |
Succinate Dehydrogenase A, Succinate dehydrogenase complex flavoprotein subunit |
88,342 |
Succinate dehydrogenase (SDH), also known as or succinate-coenzyme Q reductase or respiratory Complex II, is a heterotetrameric enzyme complex located in the inner mitochondrial membrane and participates in both the citric acid cycle and the respiratory c |
| 6291 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SDHB (EPR13042B) |
Succinate Dehydrogenase B |
88,342 |
Succinate dehydrogenase (SDH), also known as or succinate-coenzyme Q reductase or respiratory Complex II, is a heterotetrameric enzyme complex located in the inner mitochondrial membrane and participates in both the citric acid cycle and the respiratory c |
| 6292 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SF-1 (N1665) |
Steroidogenic Factor 1, NR5A1, AD4BP, FTZ-F1 |
88,342 |
Steroidogenic factor 1 (SF-1), is a nuclear hormone receptor that plays an important role in steroidogenesis, development of gonads and adrenal glands, sexual differentiation and reproduction. SF-1 is expressed in all the major steroidogenic tissues such |
| 6293 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SMAD4 (EP618Y) |
DPC4, MADH4, Deletion Target In Pancreatic Carcinoma 4 |
88,342 |
SMAD4 (mothers against decapentaplegic homolog 4 drosophila) is a tumor suppressor gene that plays a critical role in the transforming growth factor-beta (TGF-beta) signaling pathway, which regulates cellular proliferation, differentiation, and apoptosis. |
| 6294 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SMARCA2 (D9E8B) |
BRM, SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2 |
88,342 |
SMARCA2, also known as BRM (Brahma) is an important catalytic component of the SWI/SNF chromatic remodeling complex. Loss of expression of SMARCA2 has been observed in small cell carcinoma of the ovary. Undifferentiated carcinomas of the gastrointestinal |
| 6295 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SMARCA4 (EPNCIR111A) |
BRG1 |
88,342 |
SMARCA4, also known as BRG1, is a component of the SWI/SNF chromatin remodeling complex which alters DNA-histone contacts with a nucleosome in an ATP-dependent manner. The SWI/SNF complex also functions as a tumor suppressor by regulating transcription an |
| 6296 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SMMS1 (SMMS1) |
Smooth Muscle Myosin Heavy Chain |
88,342 |
SMMS-1 is a mouse monoclonal antibody that highlights the myoepithelial cell layer. The absence of a myoepithelial cell layer aids the pathologist in determining the invasive nature of a breast lesion. SMMS-1 is an important sensitive and specific marker |
| 6297 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SOX-10 (BC34) |
SRY-related high-mobility group HMG box gene 10 |
88,342 |
SOX10 (SRY-related high-mobility group HMG box gene 10) protein is a nuclear transcription factor. SOX10 acts as a nucleocytoplasmic shuttle protein and is essential for the survival of neural crest-derived cells and for the maintenance of the multi-poten |
| 6298 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SOX-11 (MRQ-58) |
SRY (sex determining region Y)-box 11 |
88,342 |
Mantle cell lymphoma (MCL) is an aggressive disease and accounts for 5 to 10% of B-cell lymphomas. Distinction of MCL from its morphologic mimics is important for appropriate therapy and prognosis. CD5, CD10, CD23, and cyclin D1 have been used as major ma |
| 6299 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SS18-SSX (E9X9V) |
Synovial sarcoma translocation, chromosome 18 fusion protein |
88,342 |
The SS18-SSX fusion proteins results from in-frame fusions of the SS18 gene on chromosome 18 with X chromosome genes SSX1, SSX2, and SSX4. Synovial sarcoma is a soft tissue malignancy with poor prognosis in which 95% harbor recurrent translocation of the |
| 6300 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SSTR2A (UMB1) |
Somatostatin Receptor 2 |
88,342 |
Expressed in many cell types, somatostatin receptor 2A (SSTR2A) is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. It also stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensi |
| 6301 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SSX (E5A2C) |
Synovial Sarcoma, X |
88,342 |
The SSX antibody recognizes endogenous levels of total SSX1-4 proteins and can detect the SS18-SSX fusion protein. SS18-SSX fusion proteins results from in-frame fusions of the SS18 gene on chromosome 18 with X chromosome genes SSX1, SSX2, and SSX4. Synov |
| 6302 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
STAT6 (YE361) |
Signal transducer and activator of transcription 6 |
88,342 |
Differentiating solitary fibrous tumour (SFT) from other benign mesenchymal tumors is difficult. The recently discovered NAB2-STAT6 translocation is present in most cases of SFT and results in the expression of a fusion protein in which the repressor doma |
| 6303 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
SV40 (MRQ-4) |
SV40 large T-antigen/Simian Virus 40/Anti-SV40 T Antigen |
88,342 |
Polyomavirus-associated nephropathy (PVAN) is an emerging disease in renal transplant patients with impaired T-cell immunity. BK virus (BKV) is the primary etiological agent, but JC virus (JCV) and possibly simian virus 40 (SV40) may account for some case |
| 6304 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Synaptophysin (SYP/3551) |
SYP, MRX96, Major Synaptic Vesicle Protein P38 |
88,342 |
Synaptophysin, a 38 kD glycoprotein, is the major integral membrane protein of synaptic vesicles. Major concentrations of the protein are found in the trans-Golgi region, in the presynaptic vesicles of neurons (brain, spinal cord, retina, neuromuscular ju |
| 6305 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Syph (T.Pallidum) (P) |
SPIROCHETE, T. PALLIDUM |
88,342 |
Treponema pallidum (Spirochete) is the causative agent of syphilis. Treponema pallidum can now be successfully localized with immunohistochemical techniques in formalin-fixed paraffin-embedded tissue. Studies have shown this offers a substantial advantage |
| 6306 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Tau (BSB-115) |
Tau protein |
88,342 |
Detection of neurofibrillary tangles and amyloid pathology are required for the diagnosis of Alzheimer’s disease. Both tangles and plaques may be detected by histochemical stains or by immunohistochemistry. Guidelines published by the National Institute |
| 6307 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TCL-1A (1-21) |
T-cell leukemia/Lymphoma Protein 1A |
88,342 |
T-cell leukemia/Lymphoma Protein 1A (TCL1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal r |
| 6308 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TCR beta F1 (8A3) |
T Cell Receptor Beta Locus F1 |
88,342 |
The T cell immune receptor consists of a heterodimer comprising the antigen recognition chains and the invariant CD3 complex. Approximately 85% of T cells contain the alpha/beta heterodimer, the other 15% bear the gamma/delta heterodimer. The γδ T-cells a |
| 6309 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TCR delta (H-41) |
T cell antigen receptor δ |
88,342 |
Gamma-delta T-cells are a subset of CD3 positive CD4/CD8 negative T-cells with a relatively poorly understood function. While they mature in the thymus like their alpha-beta counterparts, they appear to recognize multiple antigens including self and non- |
| 6310 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TdT (SEN28) |
Terminal Deoxynucleotidyl Transferase |
88,342 |
TdT is overexpressed in B- and T-cell acute lymphocytic leukemias (ALL) and in a subset acute myeloid leukemias (AML) including AML with minimal differentiation. About 90% of patients with ALL show variable levels of TdT expression as well as multiple iso |
| 6311 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Thyroglobulin (2H11+6E1) |
Tg |
88,342 |
This antibody labels thyroglobulin in thyroid tissue and is a useful aid for the classification of well differentiated thyroid carcinomas. Thyroglobulin (Tg) is a glycoprotein with a predominant form as a 660 kDa homodimer. Tg, the precursor of thyroid h |
| 6312 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TIA (TIA-1) |
T cell intracytoplasmic antigen |
88,342 |
TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas |
| 6313 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Tpit (CL6251) |
TBX19, T-Box Transcription Factor 19 |
88,342 |
Tpit (T-box family member TBX19) regulates the proopiomelanocortin (POMC) lineage giving origin to the corticotrophs within the pituitary gland. The nuclear expression of the pituitary specific transcription factors such as Tpit within pituitary tumors ce |
| 6314 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Transthyretin (BSB-125) |
Prealbumin, TTR |
88,342 |
Transthyretin is used in the diagnosis amyloidosis, a progressive condition characterized by deposits of the protein amyloid in the body's organs and tissues. There are several types of systemic amyloidosis: primary (caused by monoclonal immunoglobulins); |
| 6315 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TRPS1 (SP532) |
Transcriptional Repressor GATA Binding 1, LGCR |
88,342 |
The trichorhinophalangeal syndrome 1 (TRPS1) gene belongs to the GATA transcription factor family. It is a specific gene for breast carcinomas including ER/PR positive luminal A and B tyles, HER2-positive type, and basal-type TNBC. TRPS1 has no or little |
| 6316 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Trypsin (EPR19498-15) |
bovine trypsin, pancreatic trypsin, Alpha-1 anti-trypsin |
88,342 |
Trypsin is a serine protease produced by pancreatic acinar cells and serves as a valuable diagnostic marker in surgical pathology. Trypsin immunohistochemistry (IHC) is utilized to confirm acinar cell differentiation, aiding in the classification of pancr |
| 6317 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Tryptase (AA1) |
TRYPTASE, MAST CELL |
88,342 |
Human mast cell tryptases (EC 3.4.21.59) comprise a family of trypsin-like neutral serine proteases that are predominantly expressed in mast cells. In its enzymatically active form, mast cell tryptase exists as a non-covalently linked tetramer of 132 kDa. |
| 6318 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TSH (EP254) |
Thyroid stimulating hormone, thyrotropin |
88,342 |
Anti-TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with TSH-producing cells (thyrotrophs). |
| 6319 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
TTF-1 (8G7G3/1) |
Thyroid Transcription Factor 1 |
88,342 |
Thyroid transcription factor 1 (TTF-1) is a 38 kDa nuclear protein member of the family of homeodomain transcription factors. TTF-1 expression was originally demonstrated in follicular cells of the thyroid gland and subsequently found in the respiratory c |
| 6320 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Tyrosinase (T311) |
TYR, OCAIA |
88,342 |
Patient tissues are stained using the same conditions that were used in the validation study. The specificity of the interaction between the primary antibody or the nucleic acid probes and their targets allows confident identification of the targets in th |
| 6321 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
Vimentin (V9) |
VIM |
88,342 |
Vimentin reacts with the 57kD intermediate filament protein, vimentin. Vimentin is a single peptide that was initially isolated from chicken embryo fibroblasts. It is the major and usually only intermediate filament in a variety of non-muscle mesenchymal |
| 6322 |
gannonn2 |
11/09/2026 10:28 AM |
gannonn2 |
11/09/2026 10:28 AM |
WT1 (6F-H2) |
Wilms’ Tumor 1 |
88,342 |
WT1 encodes a zinc finger transcription factor which encodes the early growth response (EGR-1) consensus sequence found in promoters of growth factor genes. WT1 is involved in the induction of Wilms’ tumor, a pediatric renal malignancy, and is normally e |
