Porphyrins, Fractionation and Quantitation, Urine
Test Mnemonic
UPORFR
CPT Codes
- 84120 - QTY (1)
Aliases
- Cutaneous Porphyria Screen
- PCT Screen
- Porphyria Cutanea Tarda
Includes
- Creatinine, Ur mg/dL
- Creatinine mg/day
- Uroporphyrin-ratio to CRT
- Heptacarboxylate-ratio to CRT
- Coproporphyrin I-ratio to CRT
- Coproporphyrin III-ratio to CRT
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, 24-hour (well-mixed) | Clean container | Refrigerate during collection. | Frozen | Protect from light. Transfer aliquot to amber transport tube and record total volume and collection time interval on specimen and requisition. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, random | Clean container | Frozen | Protect from light. Transfer aliquot to amber transport tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 4 Days |
| Frozen | 1 month |
Days Performed
Mon - Fri
Turnaround Time
2 - 6 days
Methodology
| Name | Description |
|---|---|
| High Performance Liquid Chromatography (HPLC) |
Reference Range
| Coproporphyrin III-ratio to CRT | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 14 | umol/mol crt | |||
| Coproporphyrin I-ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 6 | umol/mol crt | |||
| Heptacarboxylate-ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 2 | umol/mol crt | |||
| Uroporphyrin | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 10 | % | Normal | 0 - 30 | % |
| Uroporphyrin-ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 4 | umol/mol crt |
Special Info
Protect from light. Record total volume and collection time interval on amber transport tube. Body fluids other than urine are unacceptable. This test is New York DOH approved.
Clinical Info
This test is useful to evaluate cutaneous photosensitivity to exclude or include porphyria cutanea tarda (PCT). Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine). Evaluation of neurologic and/or psychiatric symptoms associated with acute attack forms of porphyrias such as acute intermittent porphyria (AIP) require urine porphobilinogen (PBG) testing. If testing for an acute porphyria, please consider ordering PBG, Screen (SQUPBG). If testing for a cutaneous porphyria, please consider ordering Porphyrins, Urine (SQUPORFR). If testing for erythropoietic porphyria, please consider ordering Total Erythrocyte Porphyrins (SQPROPOR).