Neisseria meningitidis Tetravalent Antibodies, IgG (Vaccine Response)
Test Mnemonic
NMEN
CPT Codes
- 86741 - QTY (4)
Aliases
- Neisseria meningitidis Tetravalent Antibodies
Includes
- N.meningitidis Type A IgG
- N.meningitidis Type C IgG
- N.meningitidis Type Y IgG
- N.meningitidis Type W-135 IgG
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1.5 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection and transfer into standard aliquot tube. Postimmunization specimen must be collected 30 days after preimmunization specimen. Label specimens plainly as 'postimmunization' or 'preimmunization' so that specimens will be saved and tested simultaneously. Postimmunization specimen must be received within 60 days of preimmunization specimen. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.25 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
Days Performed
Mon
Turnaround Time
2 - 9 days
Methodology
| Name | Description |
|---|---|
| Quantitative Multiplex Bead Assay |
Reference Range
Special Info
Postimmunization specimen must be collected 30 days after preimmunization specimen. Label specimens plainly as 'postimmunization' or 'preimmunization' so that specimens will be saved and tested simultaneously. Postimmunization specimen must be received within 60 days of preimmunization specimen. Contaminated, hemolyzed or severely lipemic specimens will be rejected. This test is New York state approved.
Clinical Info
This test is useful to assess immunocompetence following Neisseria meningitidis vaccination. To assess suspected immunodeficiency, use pre- and postvaccination serology. Do not use for diagnosis of infection or serotyping. Responder status is determined according to the ratio of the one month post-vaccination concentration to pre-vaccination concentration of IgG antibodies to N. meningitidis (Types A, C, Y, and W-135) as follows: 1. If the one month post-vaccination concentration is less than 3.0 µg/mL, the patient is considered to be a non-responder. 2. If the one-month post-vaccination concentration is greater than or equal to 3.0 µg/mL, a patient with a ratio of greater than or equal to 4 is a good responder, a ratio of 2-4 is a weak responder, and a ratio of less than 2 is considered a non-responder.