Clobazam
Test Mnemonic
CLOBAZ
CPT Codes
- 80339 - QTY (1)
- G0480 - QTY (1)
Aliases
- Desmethylclobazam
- N-desmethylclobazam
- Norclobazam
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Serum | No additive (Red) | Refrigerated | Draw specimen immediately before next scheduled dose; trough specimens recommended as therapeutic ranges are based on trough collections. Centrifuge within 2 hours of collection and transfer serum into standard plastic aliquot tube. Serum gel tube is not acceptable. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.35 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |
Days Performed
Tue, Thu
Turnaround Time
2 - 6 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Clobazam | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 30 - 300 | ng/mL | |
| N - desmethylclobazam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 300 - 3000 | ng/mL |
Special Info
Do not draw serum separator tubes. Draw specimen immediately before next scheduled dose. Trough specimens are recommended as therapeutic ranges are based on specimens drawn immediately before the next dose. This test is available for New York state.
Clinical Info
Useful for monitoring clobazam therapy. The results of this test should be interpreted in conjunction with the patient’s physical signs, symptoms, and other laboratory test results. Most individuals display optimal response to clobazam when serum levels of clobazam are between 30 - 300 ng/mL and n-desmethylclobazam are between 300 - 3000 ng/mL. When cloabzam levels are > 500 ng/mL or n-desmethylclobazam levels are > 5000 ng/mL, risk of toxicity is increased. Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range. Therefore, interpretation should include clinical evaluation.