Mannose Binding Lectin
Test Mnemonic
MANNO
CPT Codes
- 83520 - QTY (1)
Aliases
- Mannose Binding Protein
Includes
- Mannose Binding Lectin
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Frozen | Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube and freeze. Separate specimens must be submitted when multiple tests are ordered. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Frozen | Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube and freeze. Separate specimens must be submitted when multiple tests are ordered. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 48 hours |
| Refrigerated | After separation from cells: 7 days |
| Frozen | After separation from cells: 30 days (avoid repeated freeze/thaw cycles) |
Days Performed
Tue
Turnaround Time
2 - 9 days
Methodology
| Name | Description |
|---|---|
| Enzyme-Linked Immunosorbent Assay (ELISA) |
Reference Range
| Mannose Binding Lectin | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Greater than or equal to 76 ng/mL |
Special Info
Separate specimens must be submitted when multiple tests are ordered. Non-serum, contaminated, or heat-activated specimens will be rejected. This test is New York DOH approved.
Clinical Info
The lowest reportable result is <40. This test is useful for initial screening for suspected deficiency in the lectin complement pathway. Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.