Adenosine Deaminase, Serum
Test Mnemonic
SAD
CPT Codes
- 84311 - QTY (1)
Performing Laboratory
Cambridge Biomedical
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Frozen, ASAP | Do not use serum separator tubes; Centrifuge, aliquot and freeze ASAP |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 1 week |
| Frozen | 3 months |
Days Performed
Varies (one day/week)
Turnaround Time
8 - 10 days
Methodology
| Name | Description |
|---|---|
| Colorimetry |
Reference Range
| Adenosine Deaminase | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 0 - 15 | units/L |
Special Info
Allow blood to clot for 30 minutes prior to centrifugation. Hemolyzed specimens will be rejected. Ambient temperature specimens and specimens outside of listed stability are unacceptable.
Clinical Info
Adenosine Deaminase (ADA) is an enzyme catalyzing the deamination of adenosine to inosine. The enzyme is widely distributed in human tissues, especially high in T lymphocytes. Elevated serum ADA activity has been observed in patients with acute hepatitis, alcoholic hepatic fibrosis, chronic active hepatitis, liver cirrhosis, viral hepatitis, and hepatoma. Increased ADA activity has also been observed in patients with tuberculous effusions. As a marker of cellular immunity, activity is found to be elevated in those diseases in which there is a cellmediated immune response. Numerous studies have demonstrated that CSF-ADA estimation is useful in the diagnosis of Tuberculous meningitis (TBM) and can differentiate TBM from normal subjects or from patients with other neurological disorders.