Aldosterone/Direct Renin Ratio | Cleveland Clinic Laboratories

Aldosterone/Direct Renin Ratio Print

Test Mnemonic

ALDREN

CPT Codes

84244 - QTY (1)
82088 - QTY (1)

Includes

Aldosterone
Renin

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
2 mL	Plasma	EDTA (Lavender)	Ambient	Frozen, Critical	Centrifuge and remove plasma from cells within 4 hours of collection. Freeze plasma immediately after separation from cells.

Stability

Environmental Condition	Description
Frozen	30 days
Ambient	Unacceptable
Refrigerated	Unacceptable

Days Performed

Mon - Fri

Turnaround Time

2 - 7 days

Methodology

Name	Description
Chemiluminescence Immunoassay (CLIA)

Reference Range

Aldos/Renin Ratio
Sex	Age From	Age To	Type	Range	Range Unit
				<3.8
Aldosterone, Plasma
Sex	Age From	Age To	Type	Range	Range Unit
	1 Months	12 Months	Normal	5.8 - 110.0	ng/dL
	1 Years	5 Years	Normal	< 36.0	ng/dL
	6 Years	9 Years	Normal	< 24.0	ng/dL
	10 Years	11 Years	Normal	< 15.0	ng/dL
	12 Years	14 Years	Normal	< 22.0	ng/dL
	15 Years	17 Years	Normal	3.0 - 32.0	ng/dL
	18 Years	99 Years	Normal	3.1 - 35.4	ng/dL
				0 - 30 Days: Not established
Direct Renin
Sex	Age From	Age To	Type	Range	Range Unit
	Years	40 Years	Normal	Upright: 4.2-52.2	pg/mL
	41 Years	99 Years	Normal	Upright: 3.6-81.6	pg/mL
	Years	40 Years	Normal	Supine: 3.2-33.2	pg/mL
	41 Years	99 Years	Normal	Supine: 2.5-45.1	pg/mL

Special Info

Fasting specimens are recommended but not required. Record the time of day and patient's posture during blood collection (supine or upright). DO NOT pre-chill collection tubes, store tubes on ice or refrigerate; cryoactivation of prorenin occurs when samples are refrigerated. Biotin levels of up to 100 mg/day have not shown interference with this assay. Patients taking >100 mg/day to 300 mg/day should refrain from taking Biotin for 1 hour prior to sample collection. Patients taking a Biotin dose >300 mg/day should consult with their physician or the laboratory prior to having a sample taken. Clinicians should consider biotin interference as a source of error, when clinically suspicious of the laboratory result.

Clinical Info

Diagnosis of disorders of the renin-angiotensin-aldosterone system. An increased Aldo/Renin ratio is suggestive, but not diagnostic of primary aldosteronism if aldosterone concentration is > 15 ng/dL. Normal serum levels of aldosterone are dependent on the sodium intake and whether the patient is upright or supine. High sodium intake will tend to suppress serum aldosterone, whereas low sodium intake will elevate serum aldosterone. The reference interval for serum aldosterone are based on normal sodium intake.

Clinical Limitation

Criteria for Rejection: Refrigerated, grossly hemolyzed, grossly lipemic, and obviously microbially contaminated samples will be rejected. Interfering substances: Prorenin