Amitriptyline/Nortriptyline




Test Mnemonic

AMINOR

CPT Codes

  • 80335/G0480 - QTY (1)

Aliases

  • Elavil
  • Elatrol
  • Endep
  • Etrafon
  • Laroxyl
  • Limbitrol
  • Saroten
  • Trepiline
  • Triavil
  • Tryptizol
  • Vanatrip

Includes

  • Amitriptyline
  • Nortriptyline
  • Total Amitriptyline/Nortriptyline

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumNo additive (Red) RefrigeratedCollect immediately prior to next dose. Do not use gel separator tubes. Separate serum from cells ASAP or within 2 hours of collection and transfer into a standard aliquot tube.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLPlasmaEDTA (Lavender) RefrigeratedCollect immediately prior to next dose. Do not use gel separator tubes. Separate plasma from cells ASAP or within 2 hours of collection and transfer into a standard aliquot tube.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mL     

Stability

Environmental Condition Description
Ambient5 days
Frozen6 months
Refrigerated2 weeks

Days Performed

Mon, Wed, Fri

Turnaround Time

2 - 8 days

Methodology

Name Description
Quantitative Liquid Chromatography - Tandem Mass Spectrometry 

Reference Range

Amitriptyline
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormalNot Establishedng/mL
Amitriptyline and Nortriptyline
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormalTherapeutic Range: 95 - 250ng/mL
       NormalToxic Level: Greater than 500ng/mL
Nortriptyline alone
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormalTherapeutic Range: 50 - 150ng/mL

Special Info

Collect immediately prior to next dose. Do not collect in a gel separator tube. This test is New York DOH approved.

Clinical Info

This test is useful for optimizing drug therapy and monitoring patient adherence. The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause anticholinergic effects, cardiac abnormalities and seizures.