Anti-cN-1A (NT5c1A) IBM




Test Mnemonic

CN1AAB

CPT Codes

  • 83516 - QTY (1)

Aliases

  • Anti-IBM
  • IBM
  • Inclusion Body Myopathy
  • MUP44 AB
  • nt5c1a
  • sIBM
  • sporadic IBM

Includes

  • Anti-cN-1A (NT5c1A) IBM

Performing Laboratory

Mayo Clinic Dpt of Lab Med & Pathology


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mLSerumNo additive (Red) RefrigeratedAllow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mLSerumSST (Gold) RefrigeratedAllow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mL    Does not allow for repeat testing

Stability

Environmental Condition Description
Refrigerated14 days
Frozen60 days
Ambient7 days

Days Performed

Mon - Fri

Turnaround Time

17 - 26 days

Methodology

Name Description
Enzyme-Linked Immunosorbent Assay (ELISA) 

Special Info

Grossly hemolyzed, lipemic or icteric specimens will be rejected. This test is New York DOH approved.

Clinical Info

Anti-cN-1A autoantibodies in idiopathic inflammatory myopathy (IIM) patients appear to be disease-specific for sporadic Inclusion Body Myositis (sIBM) and are rarely detected in other autoimmune conditions. Anti-cN-1A autoantibodies have a moderate sensitivity, but their high specificity for sIBM may be helpful in the diagnosis of this infrequent and difficult-to-diagnose myopathy. This assay can augment and accelerate the suspected diagnosis of sIBM using sera where muscle biopsy is delayed and/or unfeasible.