Anti-cN-1A (NT5c1A) IBM
Test Mnemonic
CN1AAB
CPT Codes
- 83516 - QTY (1)
Aliases
- Anti-IBM
- IBM
- Inclusion Body Myopathy
- MUP44 AB
- nt5c1a
- sIBM
- sporadic IBM
Includes
- Anti-cN-1A (NT5c1A) IBM
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
Specimen Requirements
Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
---|---|---|---|---|---|
2 mL | Serum | No additive (Red) | Refrigerated | Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube. |
Alternate Specimen Requirements
Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
---|---|---|---|---|---|
2 mL | Serum | SST (Gold) | Refrigerated | Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube. |
Minimum Specimen Requirements
Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
---|---|---|---|---|---|
0.5 mL | Does not allow for repeat testing |
Stability
Environmental Condition | Description |
---|---|
Refrigerated | 14 days |
Frozen | 60 days |
Ambient | 7 days |
Days Performed
Mon - Fri
Turnaround Time
17 - 26 days
Methodology
Name | Description |
---|---|
Enzyme-Linked Immunosorbent Assay (ELISA) |
Special Info
Grossly hemolyzed, lipemic or icteric specimens will be rejected. This test is New York DOH approved.
Clinical Info
Anti-cN-1A autoantibodies in idiopathic inflammatory myopathy (IIM) patients appear to be disease-specific for sporadic Inclusion Body Myositis (sIBM) and are rarely detected in other autoimmune conditions. Anti-cN-1A autoantibodies have a moderate sensitivity, but their high specificity for sIBM may be helpful in the diagnosis of this infrequent and difficult-to-diagnose myopathy. This assay can augment and accelerate the suspected diagnosis of sIBM using sera where muscle biopsy is delayed and/or unfeasible.
Clinical Limitation
n/a
Clinical Reference
n/a