- 85307 - QTY (1)
- Activated Protein C Resistance
Cleveland Clinic Laboratories
|Sodium citrate (Lt. Blue)
Minimum Specimen Requirements
|14 days at -20 C; 6 months at -70 C
Mon - Fri
1 - 3 days
3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. Patient should not be on heparin therapy or DTI therapy.
Evaluation of hypercoagulable states and thrombotic disease. Factor V Leiden PCR assay can be used to confirm APC resistance due to factor V Leiden. Ratios less than 2.07 suggest APC - resistance. High heparin concentrations (> 1 U/mL) and direct thrombin inhibitor drugs may interfere with test results. Lupus anticoagulant and other coagulation inhibitors may also interfere with test results. Causes of APC resistance other than abnormalities of factor V may not be detected by this assay as all factors except factor V are replaced in the assay.