B Cell CD20 Expression
Test Mnemonic
CD20
CPT Codes
- 88184 - QTY (1)
- 88185 - QTY (1)
Aliases
- CD20 on B Cells
- Rituximab Therapy CD20
Includes
- Interpretation
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Whole blood | Sodium heparin (Green) | Ambient | Specimen should be received at Cleveland Clinic Laboratories by 1:00 p.m. on the day of collection. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Whole blood | EDTA (Lavender) | Ambient | Specimen should be received at Cleveland Clinic Laboratories by 1:00 p.m. on the day of collection. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
Days Performed
Sun - Sat
Turnaround Time
2 - 3 days
Special Info
Specimen should be received by performing lab within 48 hours of collection for optimal viable testing. Provide CBC, Wright's stained smear, clinical history, differential diagnosis and any relevant pathology reports. Frozen, clotted, or hemolyzed specimens will be rejected. Specimens greater than 48 hours old are unacceptable. This test is New York DOH approved.
Clinical Info
Monoclonal antibody based therapies that target the CD20 antigen such as Rituximab are being used to treat patients with a variety of B-cell lymphomas and leukemias. The effectiveness of these therapies requires that the B-cell leukemia or lymphoma cells express CD20. This test examines whether surface CD20 antigen expression can be identified on any B-cells present in the submitted specimen.