FISH for Angiosarcoma MYC Amplification

Test Mnemonic


CPT Codes

  • 88377 - QTY (1)




  • LSI 14q32
  • LSI 8q24

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 slidesSlide (s), unstained AmbientAmbientOne formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative


Environmental Condition Description
AmbientSample is formalin fixed and must not be fixed in Prefer or B5.

Days Performed

5 days per week

Turnaround Time

5 - 7 days


Name Description
Fluorescent In-Situ Hybridization (FISH) 

Clinical Info

Interphase FISH analysis utilizing an enumeration probe specific to the MCY gene at 8q24.1, in association with the IGH gene at 14q32.33. Used in the differentiation of cutaneous angiosarcomas from atypical vascular lesions after radiotherapy, as well as the diagnosis of primary cutaneous angiosarcoma. If no cells are available for analysis, no analysis chares will be incurred.