FISH for BCL2 (18q21) Tissue

Test Mnemonic


CPT Codes

  • 88377 - QTY (1)


  • FISH for 18q21

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 slidesSlide (s), unstainedClean container AmbientOne formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative


Environmental Condition Description
AmbientBlocks and slides should be transported at ambient temperature.

Days Performed

5 days per week

Turnaround Time

3 - 5 days


Name Description
Fluorescent In-Situ Hybridization (FISH) 

Reference Range

Clinical Info

Interphase FISH analysis utilizing a dual color, break-apart probe for the BCL2 gene at 18q21.33. Rearrangements of the BCL2 gene are observed in various B-cell lymphomas. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.