FISH for Cutaneous Melanoma

Test Mnemonic


CPT Codes

  • 88377 - QTY (2)


  • FISH for 6p24.1, 6q23.3, 11q13.3, CEP 6
  • FISH for 9p21.3, 8q24.21, CEP 9

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
ThreeSlide (s), unstainedClean container  One formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative


Environmental Condition Description
AmbientFFPE tissue block or unstained slides from FFPE tissue are stable in ambient environment.

Days Performed

5 days per week

Turnaround Time

6 - 10 days


Name Description
Fluorescent In-Situ Hybridization (FISH) 

Clinical Info

Two interphase FISH assays detecting copy number variations of the RREB1 (6p23.3), MYB (6q23.3), CCND1 (11q13.3), and CDKN2A (9p21.3) genes, as well as MYC (8q24.21) amplification. Useful in diagnosing and classifying cutaneous melanoma. If no cells are available for analysis, no analysis charges will be incurred.